Indima kaI-Trimethylamine Hydrochloride (TMA Hcl)Ku-carnitine kulele ekusetshenzisweni kwayo njengezinto zokusetshenziswa zamakhemikhali (ezihlinzeka ngamaqembu e-trimethylamine) ukukhiqiza i-carnitine. Kalula nje, ingenye "yezinsika" zokukhiqiza i-carnitine.

Ekukhiqizweni kwezimboni, indlela yokwenziwa kwe-carnitine cishe ilandelayo:

·Nikeza isakhiwo esiyisihluthulelo:

I-Trimethylaminhydrochlorideinikeza i-trimethylamine kuma-reactants, okuyingxenye ebalulekile yesakhiwo se-quaternary ammonium kuma-molecule e-carnitine.

·Inqubo ethile yokuhlanganisa:

Embonini, kusukela ku-epichlorohydrin,I-Trimethylamine Hydrochlorideingezwa ukuze kutholakale ukusabela kwe-amination. Ngemva kwezinyathelo ezilandelayo njenge-cyanide kanye ne-hydrolysis, i-carnitine itholakala ekugcineni.

·Kwenziwe ngesimo sikasawoti:

Ukuze kuthuthukiswe ukuzinza nokwandisa isikhathi sokuphila, i-carnitine eyenziwe ivame ukusabela ne-hydrochloric acid ukuze kukhiqizwe i-carnitine hydrochloride, elula ukuyigcina nokuthuthwa.

I-L-carnitineisetshenziswa kakhulu njengesithuthukisi sokudla okunempilo kanye nesikhuthazi se-metabolism yamandla ekudleni.
Kuyi-amino acid etholakala ngokwemvelo engakhuthaza ukuwohloka kwamafutha emizimbeni yezilwane futhi ithuthukise ukusebenza kahle kokusetshenziswa kwamandla. Ukwengeza i-L-carnitine ekudleni kunemisebenzi ebalulekile elandelayo:

1. Ukukhuthaza ukugaya amafutha:

I-L-carnitine iyisithwali esibalulekile sama-fatty acids amade ukuze angene e-mitochondria ukuze kutholakale i-β-oxidation, okungathuthukisa kakhulu ukusetshenziswa kwamafutha ezilwane futhi kunciphise ukubekwa kwamafutha emzimbeni.

2. Ukuthuthukisa ukusebenza kokukhula:

Ngokuthuthukisa imetabolism yamandla, izinga lokuguqulwa kokudla lingakhushulwa, kukhuthazwe ukukhuluphala kwezilwane, ikakhulukazi okufanelekela imfuyo kanye nezinkukhu ngesikhathi sokukhuluphala. Ucwaningo lukhombisile ukuthi ukwengeza i-L-carnitine engu-50-100mg/kg ekudleni kwezingulube kungakhuphula ukukhuluphala kwansuku zonke ngo-5-8%.

3. Ukuthuthukisa ukusebenza kokuzala:

Ukuyifaka ekudleni kwezilwane kungandisa ukuhamba kwesidoda, izinga lokukhulelwa, kanye nosayizi wesilwane. Isilinganiso esinconywayo sokuzalanisa izingulube singu-100-150mg/kg.

4. Thuthukisa ukumelana nokucindezeleka:

Kungathuthukisa ukuphazamiseka kwe-metabolic kwezilwane ngaphansi kwezimo zokucindezeleka njengokushisa okuphezulu kanye nokuhamba, futhi kugcine imisebenzi evamile yomzimba.

5. Thuthukisa ikhwalithi yenyama:

ukunciphisa ukwakheka kwamafutha, ukwandisa isilinganiso semisipha, nokuthuthukisa ikhwalithi yenyama.

Izinyathelo Zokuqapha Zokusetshenziswa:
Isilinganiso esifanele sezinhlobo ezahlukene zezilwane kanye nezigaba zokukhula siyahlukahluka kakhulu, futhi kuyadingeka ukulandela ngokuqinile isilinganiso esinconywayo.
Uma isetshenziswa kanye nama-antioxidants afana ne-vitamin E kanye ne-selenium, umphumela uba ngconoUma ugcina, gwema izindawo ezinokushisa okuphezulu kanye nomswakama ophezuluUma uxuba ukudla, kubalulekile ukuqinisekisa ukuhlakazeka okufanayo