Ukusetshenziswa kwe-organic acid kungathuthukisa ukusebenza kokukhula kwezinkukhu ezikhulayo nezingulube. Paulicks et al. (1996) wenze ukuhlolwa komthamo we-titration ukuze kuhlolwe umphumela wokwanda kwezinga le-potassium dicarboxylate ekusebenzeni kwezingulube ezikhulayo. 0, 0.4, 0.8, 1.2, 1.6, 2.0, 2.4 kanye no-2.8%i-potassium dicarboxylatekwanezelwa ekuphakeleni kokuvula kwezingulube ezifunzwa ukudla okusekelwe kubhontshisi wesoya. Isilinganiso senzuzo yansuku zonke, ukudla kwansuku zonke kanye nezinga lokuguqulwa kokuphakelayo kweqembu le-potassium dicarboxylate likhuphuke ngo-13%, 9% no-4% ngokulandelana. Uma kuqhathaniswa neqembu elingalashwanga, ukungeza i-2% PD inyuse isisindo somzimba ngo-22%. Ngokwezinga eliphezulu lokungeza elibhaliswe yiziphathimandla zaseYurophu lika-1.8%, ukuzuza kwesisindo kunganyuswa ku-14%. Ukudla okudliwayo kunyuswe ngethamo elifanayo. Izinga lokuguqulwa kokuphakelayo (i-FCR) lehle ngokuhambisana nokukhuphuka kwe-PD, ukusuka ku-1.59 ukuya ku-1.47. Abanye abacwaningi bahlole umphumela we-PD ekusebenzeni kwezingulube. Ithebula 1 lifingqa imiphumela yokuhlolwa yemiphumela ye-PD ekuzuzeni isisindo (WG) kanye ne-FCR.

Imithelela ye-potassium dicarboxylate ekuzuzeni isisindo sesilwane kanye nokuguqulwa kokuphakelayo

I-Potassium dicarboxylateibhaliswe njengomgqugquzeli wokukhula ongewona ama-antibiotic, okuhloswe ngawo ukufaka ama-antibiotic esikhundleni sokuphakelayo kanye nokuqinisekisa ukufinyelela kwabathengi emikhiqizweni ephephile. Ngakho-ke, izinzuzo zokusebenzisa i-potassium dicarboxylate kufanele ziqhathaniswe nemiphumela yokusetshenziswa okujwayelekile kwama-antibiotic okuphakelayo. I-Tylosin ingenye yemithi elwa namagciwane esetshenziswa kakhulu ezingulubeni. UDanielsen (1998) uqhathanise ukusebenza kokukhula kwezingulube eziphathwe ngama-antibiotic ukukhula umgqugquzeli we-tylosin noma i-PD. Imiphumela yabonisa ukuthi i-potassium dicarboxylate ingangena esikhundleni semithi elwa namagciwane ngaphandle kwanoma yimuphi umthelela omubi ekusebenzeni kwezilwane. Ucwaningo luye lwabonisa ukuthi i-potassium dicarboxylate ithuthukisa ukusebenza kokukhula kwezilwane, futhi ukusebenza kwe-antibacterial ye-potassium dicarboxylate kuyisici esiyinhloko esithinta ukusebenza kokukhula.

Umthelela wama-asidi e-organic ekusebenzeni kokukhula awuhlobene kuphela nomphumela omubi wama-asidi e-organic kuma-microorganisms, kodwa futhi nokunciphisa i-pH yamathumbu. Ngaphezu kwalokho, ama-ion angalungile e-asidi anomphumela omuhle ku-symbiosis yezitshalo zamathumbu. Yonke le miphumela inciphisa i-metabolism ephakathi futhi isiza ukuthuthukisa ukusebenza kokukhula. Ukwenziwa ngcono kokusetshenziswa kwezakhamzimba ngokwengxenye kungenxa yokuncipha kokuncintisana kwama-microbial for imisoco, kodwa futhi kuwumphumela wokugaya okusebenzayo kwe-enzyme kwezakhi. Roth et al. (I-1998) ibike ukuthi i-1.8% ye-PD supplementation ithuthukise ukugaya, ikakhulukazi ebonisa izinguquko zomsebenzi we-microbiota wamathumbu. Njengoba cishe u-80% we-nitrogen esendle uvela ezinambuzaneni, imiphumela yazo ibonisa ukuthi ukufakwa kwe-PD kunganciphisa inani lezakhi ezivubelayo ezingena ku-hindgut ngokwenza ngcono ukugayeka kwe-enzymatic emathunjini amancane. Baphinde baphakamisa ukuthi kungase kuthuthukise isimo sokucwila kwesidumbu ngokwenza ama-amino acids kube lula ukufaka amaprotheni emzimbeni. U-Partanene noMroz (1999) baveze ukuthi imithombo yamaprotheni yekhwalithi ephansi inomthelela omkhulu ekwenzeni ngcono ukugayeka kokudla amaprotheni kunemithombo yamaprotheni ekhwalithi ephezulu.

I-Potassium dicarboxylate ingathuthukisa ukuzuza kwesisindo sezilwane, ukudla okudliwayo kanye nokuguqulwa kokudla. Ukwenziwa ngcono kokusebenza kokukhula kulingana nalokho komgqugquzeli wokukhula. Ngakho-ke, i-potassium dicarboxylate isibe indawo ephumelelayo yama-antibiotic okuphakelayo ngenxa yezakhiwo zayo ezinhle kakhulu. Umthelela ku-microflora ubhekwa njengendlela eyinhloko yesenzo, futhi ayikho ingozi yokumelana ne-microbial. Yehlisa izinga le-E. coli ne-Salmonella emikhiqizweni yenyama.