Ukusetshenziswa kwama-organic acid kungathuthukisa ukusebenza kokukhula kwenkukhu ezikhulayo kanye nezingulube. UPaulicks et al. (1996) benze ukuhlolwa kwe-dose titration ukuhlola umphumela wokwandisa izinga le-potassium dicarboxylate ekusebenzeni kwezingulube ezikhulayo. 0, 0.4, 0.8, 1.2, 1.6, 2.0, 2.4 kanye no-2.8%i-potassium dicarboxylatekwenezelwa ekudleni kokuqala kwamachwane adla ubhontshisi wommbila. Isilinganiso sokukhula kwansuku zonke, ukudla kwansuku zonke kanye nesilinganiso sokuguqulwa kokudla kweqembu le-potassium dicarboxylate kwanda ngo-13%, 9% kanye no-4% ngokulandelana. Uma kuqhathaniswa neqembu elingelashwanga, ukwengeza u-2% PD kwanda isisindo somzimba ngo-22%. Ngokusho kwezinga eliphezulu lokwengeza elibhaliswe yiziphathimandla zaseYurophu elingu-1.8%, ukukhuluphala kunganda ku-14%. Ukudla kokudla kwanda ngesilinganiso esifanayo. Izinga lokuguqulwa kokudla (i-FCR) lehle ngokuhambisana nokwanda kwe-PD, kusuka ku-1.59 kuya ku-1.47. Abanye abacwaningi bahlole umphumela we-PD ekusebenzeni kwamachwane engulube. Ithebula 1 lifingqa imiphumela yokuhlola yemiphumela ye-PD ekukhuleni kwesisindo (i-WG) kanye ne-FCR.

Imiphumela ye-potassium dicarboxylate ekuzuzeni isisindo sezilwane kanye nokuguqulwa kokudla

I-Potassium dicarboxylateibhaliswe njengomgqugquzeli wokukhula ongewona owama-antibiotic, ohlose ukufaka esikhundleni sama-antibiotic ekudleni nasekuqinisekiseni ukufinyelela kwabathengi emikhiqizweni ephephile. Ngakho-ke, izinzuzo zokusebenzisa i-potassium dicarboxylate kumele ziqhathaniswe nemiphumela yokusetshenziswa njalo kwama-antibiotic okuphakelayo. I-Tylosin ingenye yama-antibiotic okuphakelayo asetshenziswa kakhulu ezingulubeni. UDanielsen (1998) waqhathanisa ukusebenza kokukhula kwezingulube eziphathwe nge-antibiotic growth promoter tylosin noma i-PD. Imiphumela ikhombisile ukuthi i-potassium dicarboxylate ingathatha indawo yama-antibiotic okuphakelayo ngaphandle komphumela omubi ekusebenzeni kwezilwane. Izifundo zikhombisile ukuthi i-potassium dicarboxylate ithuthukisa ukusebenza kokukhula kwezilwane, futhi ukusebenza kwama-antibacterial kwe-potassium dicarboxylate kuyisici esiyinhloko esithinta ukusebenza kokukhula.

Umphumela wama-organic acid ekusebenzeni kokukhula awuhlobene nje kuphela nomphumela omubi wama-organic acid kuma-microorganism, kodwa futhi nokwehla kwe-pH yamathumbu. Ngaphezu kwalokho, ama-ion amabi e-acid anethonya elihle ekuhambisaneni kwezitshalo zamathumbu. Yonke le miphumela inciphisa imetabolism ephakathi futhi isiza ekuthuthukiseni ukusebenza kokukhula. Ukuthuthukiswa kokusetshenziswa kwezakhamzimba kungenxa yokunciphisa ukuncintisana kwamagciwane ngezakhamzimba, kodwa futhi kuwumphumela wokugaya izakhamzimba okuphumelelayo kakhulu ngama-enzyme. URoth et al. (1998) babike ukuthi ukungezelelwa kwe-PD okungu-1.8% kuthuthukise ukugayeka, okubonisa kakhulu izinguquko zomsebenzi we-microbiota yamathumbu. Njengoba cishe u-80% we-nitrogen endle uvela kuma-microorganism, imiphumela yabo ikhombisa ukuthi ukungezelelwa kwe-PD kunganciphisa inani lezakhamzimba ezivundiswayo ezingena esiswini ngokuthuthukisa ukugayeka kwe-enzyme yamathumbu amancane. Baphinde basikisela ukuthi kungathuthukisa isimo sokungaqini kwesidumbu ngokwenza kube lula ukufaka ama-amino acid emzimbeni. I-Partanene noMroz (1999) baveze ukuthi imithombo yamaprotheni ekhwalithi ephansi inethonya elikhulu ekuthuthukisweni kokugayeka kweprotheni kunemithombo yamaprotheni ekhwalithi ephezulu.

I-potassium dicarboxylate ingathuthukisa ukukhuluphala kwezilwane, ukudla okudliwayo kanye nokuguqulwa kokudla. Ukuthuthukiswa kokusebenza kokukhula kufana nokomgqugquzeli wokukhula. Ngakho-ke, i-potassium dicarboxylate isibe indawo ephumelelayo yama-antibiotic okuphakelayo ngenxa yezakhiwo zayo ezinhle kakhulu. Umthelela kuma-microflora ubhekwa njengendlela eyinhloko yokusebenza, futhi akukho bungozi bokumelana nama-microbial. Inciphisa izinga lokusabalala kwe-E. coli kanye ne-Salmonella emikhiqizweni yenyama.