Iyini imiphumela ye-organic acid kanye nama-glycerides ane-acidified "ekuphikisaneni okungavunyelwe kanye nokunciphisa ukumelana" ?
Kusukela ekuvinjweni kwaseYurophu kubagqugquzeli bokukhula kwemithi elwa namagciwane (AGPs) ngo-2006, ukusetshenziswa kwe-organic acid ekudleni kwezilwane sekubaluleke kakhulu embonini yokudla. Umthelela wabo omuhle kwikhwalithi yokudla nokusebenza kwezilwane usunamashumi eminyaka ukhona, njengoba ziya ngokuya zidonsa ukunaka kwemboni yezokudla.
Ayini ama-organic acid?
I-Organic acids" ibhekisela kuwo wonke ama-acids abizwa ngokuthi ama-carboxylic acids akhelwe phezu kwe-carbon skeleton engashintsha ukwakheka kwebhaktheriya, okubangela ukuphazamiseka kwe-metabolic okuvimbela ukwanda nokuholela ekufeni.
Cishe wonke ama-asidi aphilayo asetshenziswa ekudleni kwezilwane (njenge-formic acid, i-propionic acid, i-lactic acid, i-acetic acid, i-sorbic acid noma i-citric acid) anesakhiwo se-aliphatic futhi ayimithombo yamandla yamaseli. Ngokungqubuzanayo,
i-benzoic acidyakhelwe emasongweni anephunga elimnandi futhi inezinto ezihlukene ze-metabolic kanye nokumuncwa.
Ukwengezwa kwama-asidi aphilayo ngemithamo ephezulu ngokufanele ekudleni kwezilwane kungakhuphula isisindo somzimba, kuthuthukise ukuguqulwa kwesiphakeli futhi kunciphise ukugcwala kwamagciwane emathunjini.
1, yehlisa inani le-pH namandla okubhafa ekuphakeleni kanye nemiphumela elwa namagciwane kanye ne-antifungal.
2, ngokukhulula ama-ion e-hydrogen esiswini ukuze kwehlise inani le-pH, ngaleyo ndlela kusebenze i-pepsinogen ukuze yakhe i-pepsin futhi ithuthukise ukugayeka kokudla amaprotheni;
3. Ukuvinjelwa kwamagciwane e-gram-negative emgudwini wamathumbu.
4, ama-metabolites aphakathi - asetshenziswa njengamandla.
Ukusebenza kwe-asidi ephilayo ekuvimbeleni ukukhula kwe-microbial kuncike enanini layo le-pKa, elichaza i-pH ye-asidi ku-50% esimweni sayo esingahlosiwe futhi esingahlotshaniswa. Eyokugcina yindlela lapho ama-asidi e-organic anezindawo zokulwa namagciwane. Kulapho kuphela ama-asidi e-organic esesimweni sawo esingahlangene lapho engadlula ezindongeni zamagciwane nesikhunta futhi aguqule umzimba wawo lapho abe namandla okulwa namagciwane. Ngakho-ke, lokhu kusho ukuthi ukusebenza kahle kwe-antimicrobial ye-organic acids kuphezulu ngaphansi kwezimo ezine-acidic (njengasesiswini) futhi kuncishiswe ku-pH engathathi hlangothi (emathunjini).
Ngakho-ke, ama-organic acid anamanani aphezulu e-pKa angama-asidi abuthaka kanye nama-antimicrobial asebenza kangcono ekuphakeleni ngenxa yengxenye ephezulu yamafomu angahlotshaniswa akhona ekuphakeleni, okungavikela okuphakelayo kusikhunta nama-microorganisms.
I-Acidified glyceride
Ngawo-1980, usosayensi waseMelika u-Agre wathola iphrotheni ye-cell membrane ebizwa ngokuthi i-aquaporin. Ukutholakala kwemigudu yamanzi kuvula indawo entsha yocwaningo. Njengamanje, ososayensi bathole ukuthi ama-aquaporin atholakala kabanzi ezilwaneni, ezitshalweni nasezintweni ezincane.
Ngokuhlanganiswa kwe-propionic acid ne-butyric acid ne-glycerol, i-α-monopropionic acid glycerol ester, i-α-monobutyric acid glycerol ester, ngokuvimbela amagciwane kanye nesikhunta sesiteshi se-glycerol, iphazamisa ibhalansi yabo yamandla kanye nebhalansi eguqukayo ye-membrane, ukuze ilahlekelwe imithombo yamandla, ivimbe i-energy synthesis, i-nobactericidus yezidakamizwa ukuze idlale i-nobacterium synthesis.
Inani le-pKa lama-organic acid wumphumela wawo ovimbelayo kuma-microorganisms. Isenzo sama-asidi aphilayo ngokuvamile sincike kumthamo, futhi lapho isithako esisebenzayo sifinyelela indawo yokwenza, isenzo esidingekayo siba phezulu. Lokhu kusebenza kahle kokubili ekulondolozeni ukudla kanye nemiphumela yokudla okunempilo kanye nezempilo ezilwaneni. Uma ama-asidi anamandla ekhona, usawoti wama-asidi aphilayo ungasiza ekunciphiseni umthamo wokugcinwa kwesiphakeli futhi unganikeza ama-anion ekukhiqizeni ama-asidi aphilayo.
Ama-glyceride ane-Acid anesakhiwo esiyingqayizivele, i-α-monopropionate ne-α-monobutyric glycerides, anomphumela ophawulekayo wokubulala amagciwane ku-Salmonella, i-Escherichia coli namanye amagciwane ane-gram-negative kanye ne-clostridium ngokuvimbela umzila we-water-glycerine wamagciwane, futhi lo mphumela we-bactericidal awunqunyelwe nge-PH. Ayidlali indima emathunjini kuphela, kodwa futhi le-short-chain fatty acid glyceride imuncwa ngqo egazini ngokusebenzisa amathumbu, futhi ifinyelele ezingxenyeni ezihlukahlukene zomzimba ezingenwe yilesi sifo ngokusebenzisa umthambo we-portal ukuvimbela nokulawula kangcono ukutheleleka kwebhaktheriya.
Isikhathi sokuthumela: Aug-22-2024 
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