Iyini imiphumela yama-organic acid kanye nama-glycerides ane-acid ku-"ukumelana okuvinjelwe kanye nokumelana okuncishisiwe"?
Kusukela ekuvinjelweni kweYurophu kwabagqugquzeli bokukhula kwama-antibiotic (ama-AGP) ngo-2006, ukusetshenziswa kwama-organic acid ekudleni kwezilwane kuye kwaba yinto ebaluleke kakhulu embonini yokudla. Umthelela wabo omuhle ekhwalithini yokudla kanye nokusebenza kwezilwane ube khona amashumi eminyaka, njengoba beqhubeka nokuheha ukunaka kwemboni yokudla.
Ayini ama-organic acid?
Ama-organic acid" abhekisela kuwo wonke ama-acid abizwa ngokuthi ama-carboxylic acid akhiwe phezu kwe-carbon skeleton engashintsha isakhiwo somzimba samabhaktheriya, okubangela ukungasebenzi kahle kwe-metabolic okuvimbela ukwanda futhi kuholele ekufeni.
Cishe wonke ama-asidi e-organic asetshenziswa ekudleni kwezilwane (njenge-formic acid, i-propionic acid, i-lactic acid, i-acetic acid, i-sorbic acid noma i-citric acid) anesakhiwo se-aliphatic futhi ayimithombo yamandla yamaseli. Ngokuphambene nalokho,
i-benzoic acidyakhelwe phezu kwezindandatho zephunga elimnandi futhi inezakhiwo ezahlukene ze-metabolic kanye ne-muncwa.
Ukwengezwa kwama-asidi e-organic ngemithamo ephezulu yokudla kwezilwane kungandisa isisindo somzimba, kuthuthukise ukuguqulwa kokudla futhi kunciphise ukugcwala kwamagciwane emathunjini.
1, kunciphisa inani le-pH kanye nomthamo wokubopha ekudleni kanye nemiphumela yokulwa namagciwane kanye ne-antifungal.
2, ngokukhulula ama-ion e-hydrogen esiswini ukuze kuncishiswe inani le-pH, ngaleyo ndlela kusebenze i-pepsinogen ukuze kwakhiwe i-pepsin futhi kuthuthukiswe ukugayeka kwamaprotheni;
3. Ukuvinjelwa kwamagciwane angenayo i-gram endleleni yokugaya ukudla.
4, ama-metabolite aphakathi nendawo - asetshenziswa njengamandla.
Ukusebenza kahle kwe-organic acid ekuvimbeleni ukukhula kwamagciwane kuncike enanini layo le-pKa, elichaza i-pH ye-acid ku-50% ngesimo sayo esihlukanisiwe nesingafani. Lokhu kokugcina yindlela ama-organic acid anezakhiwo zokulwa namagciwane ngayo. Kuphela uma ama-organic acid esesimo sawo esingahlukanisiwe lapho angadlula khona ezindongeni zamabhaktheriya nesikhunta futhi ashintshe indlela asebenza ngayo lapho eba namandla okulwa namagciwane. Ngakho-ke, lokhu kusho ukuthi ukusebenza kahle kwama-organic acid okulwa namagciwane kuphezulu ngaphansi kwezimo ze-acid (njengasesiswini) futhi kuncishiswe ku-pH engathathi hlangothi (emathunjini).
Ngakho-ke, ama-asidi e-organic anenani eliphezulu le-pKa angama-asidi abuthakathaka futhi asebenza kahle ekulweni namagciwane ekudleni ngenxa yesilinganiso esiphezulu sezinhlobo ezingahlukanisiwe ezikhona ekudleni, ezingavikela ukudla ezikhunta nasezilwanyaneni ezincane.
I-glyceride ene-asidi
Ngawo-1980, usosayensi waseMelika u-Agre wathola iphrotheni ye-membrane yeseli ebizwa ngokuthi i-aquaporin. Ukutholakala kwemigudu yamanzi kuvula indawo entsha yocwaningo. Njengamanje, ososayensi bathole ukuthi ama-aquaporin atholakala kakhulu ezilwaneni, ezitshalweni nasezilwanyaneni ezincane.
Ngokwenziwa kwe-propionic acid kanye ne-butyric acid kanye ne-glycerol, i-α-monopropionic acid glycerol ester, i-α-monobutyric acid glycerol ester, ngokuvimbela isiteshi se-glycerol samabhaktheriya kanye nesikhunta, kuphazamisa ibhalansi yawo yamandla kanye nebhalansi enamandla ye-membrane, ukuze alahlekelwe imithombo yamandla, avimbele ukwakheka kwamandla ukuze adlale umphumela omuhle wokubulala amagciwane, futhi kungabikho zinsalela zemithi.
Inani le-pKa lama-organic acid liwumphumela wawo wokuvimbela kuma-microorganisms. Isenzo sama-organic acid ngokuvamile sincike kumthamo, futhi uma isithako esisebenzayo sifinyelela indawo yesenzo, kulapho isenzo esidingekayo siphezulu khona. Lokhu kusebenza kokubili ekulondolozweni kokudla kanye nemiphumela yokudla kanye nempilo ezilwaneni. Uma kukhona ama-acid aqinile, usawoti wama-organic acid ungasiza ekunciphiseni amandla okugcina ukudla futhi ungahlinzeka ngama-anion ekukhiqizweni kwama-organic acid.
Ama-glyceride ane-acid anesakhiwo esiyingqayizivele, i-α-monopropionate kanye ne-α-monobutyric glycerides, anomphumela omangalisayo wokubulala amagciwane ku-Salmonella, i-Escherichia coli kanye namanye amabhaktheriya angenayo i-gram kanye ne-clostridium ngokuvimbela isiteshi samanzi-glycerine samabhaktheriya, futhi lo mphumela wokubulala amagciwane awunqunyelwe yinani le-pKa kanye nenani le-PH; Ayidlali nje indima emathunjini, kodwa futhi le-glyceride yamafutha e-short-chain imuncwa ngqo egazini ngamathumbu, futhi ifinyelela ezingxenyeni ezahlukahlukene zomzimba ezinegciwane nge-portal vein ukuze ivimbele futhi ilawule kangcono ukutheleleka kwamagciwane okusemzimbeni.
Isikhathi sokuthunyelwe: Agasti-22-2024 
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