Ama-fatty acid atholakala ku-short-chain, okuhlanganisa i-butyrate kanye nezinhlobo zayo ezitholakala kuyo, asetshenziswe njengezithasiselo zokudla ukuze kuguqulwe noma kulungiswe imiphumela emibi engaba khona yezithako ezitholakala ezitshalweni ekudleni kwezilwane zasemanzini, futhi anemiphumela eminingi eboniswa kahle ngokomzimba nangokwempilo ezincelisayo nasezilwaneni ezifuywayo. I-Tributyrin, i-butyric acid derivate, ihlolwe njengesengezo ekudleni kwezilwane ezifuywayo, ngemiphumela ethembisayo ezinhlotsheni eziningana. Ezinhlanzini nasezinkantini, ukufakwa kokudla kwe-tributyrin kusanda kwenziwa futhi akukafundwa kakhulu kodwa imiphumela iphakamisa ukuthi kungaba yinzuzo kakhulu ezilwaneni zasemanzini. Lokhu kubaluleke kakhulu ezinhlotsheni ezidla inyama, okudinga ukudla kwazo kuthuthukiswe ukuze kuncishiswe okuqukethwe kokudla kwezinhlanzi ukuze kuthuthukiswe ukuzinza kwemvelo nokonga komkhakha. Umsebenzi wamanje uchaza i-tributyrin futhi wethula imiphumela eyinhloko yokusetshenziswa kwayo njengomthombo wokudla we-butyric acid ekudleni kwezinhlobo zasemanzini. Ukugxila okuyinhloko kunikezwa ezinhlotsheni zezilwane zasemanzini nokuthi i-tributyrin, njengesengezo sokudla, ingasiza kanjani ekwenzeni ngcono ukudla kwamanzi okusekelwe ezitshalweni.
2. I-Glyceryl butyrate
I-asidi ye-butyric inephunga elingathandeki futhi kulula ukuyishintsha, futhi kunzima ukufinyelela ekugcineni kwamathumbu ukuze idlale indima ngemva kokudliwa yizilwane, ngakho-ke ayikwazi ukusetshenziswa ngqo ekukhiqizeni. I-Glyceryl butyrate ingumkhiqizo onamafutha we-butyric acid ne-glycerin. I-asidi ye-butyric ne-glycerin ziboshwe yizibopho ze-covalent. Zizinzile kusukela ku-pH1-7 kuya ku-230 ℃. Ngemva kokudliwa yizilwane, i-glyceryl butyrate ayiboli esiswini, kodwa ibola ibe yi-butyric acid ne-glycerin emathunjini ngaphansi kwesenzo se-pancreatic lipase, ikhipha kancane kancane i-butyric acid. I-Glyceryl butyrate, njengesithako sokudla, kulula ukuyisebenzisa, iphephile, ayinabo ubuthi, futhi inokunambitheka okukhethekile. Ayixazululi nje inkinga yokuthi i-butyric acid kunzima ukuyifaka njengoketshezi futhi inuka kabi, kodwa futhi ithuthukisa inkinga yokuthi i-butyric acid kunzima ukuyifinyelela endleleni yamathumbu uma isetshenziswa ngqo. Kubhekwa njengenye yemikhiqizo emihle kakhulu ye-butyric acid derivatives kanye ne-antihistamine.
2.1 I-Glyceryl Tributyrate kanye ne-Glyceryl Monobutyrate
I-TributyrinIqukethe ama-molecule amathathu e-butyric acid kanye ne-molecule eyodwa ye-glycerol. I-Tributyrin ikhipha kancane kancane i-butyric acid emathunjini nge-pancreatic lipase, ingxenye yayo ekhishwa ngaphambili kwamathumbu, futhi ingxenye yayo ingafinyelela ngemuva kwamathumbu ukuze idlale indima; I-monobutyric acid glyceride yakhiwa yi-molecule eyodwa ye-butyric acid ebopha endaweni yokuqala ye-glycerol (indawo ye-Sn-1), enezakhiwo ze-hydrophilic kanye ne-lipophilic. Ingafinyelela ekugcineni kwamathumbu ngejusi lokugaya ukudla. I-butyric acid ethile ikhishwa yi-pancreatic lipase, kanti enye imuncwa ngqo ngamaseli e-epithelial emathunjini. Ibola ibe yi-butyric acid kanye ne-glycerol kumaseli e-mucosal emathunjini, ikhuthaza ukukhula kwe-intestinal villi. I-Glyceryl butyrate ine-polarity yama-molecule kanye ne-nonpolarity, engangena ngempumelelo kulwelwesi lweseli olu-hydrophilic noma lwe-lipophilic lwamagciwane amakhulu abangela izifo, ihlasele amaseli ebhaktheriya, ibhubhise isakhiwo seseli, futhi ibulale amabhaktheriya ayingozi. I-monobutyric acid glyceride inomphumela oqinile wokulwa namagciwane kumagciwane ane-gram-positive kanye namagciwane ane-gram-negative, futhi inomphumela ongcono wokulwa namagciwane.
2.2 Ukusetshenziswa kwe-glyceryl butyrate emikhiqizweni yasemanzini
I-Glyceryl butyrate, njenge-derivative ye-butyric acid, ingakhipha ngempumelelo i-butyric acid ngaphansi kwesenzo se-pancreatic lipase yamathumbu, futhi ayinaphunga, izinzile, iphephile futhi ayinazo izinsalela. Ingenye yezindlela ezinhle kakhulu zokusebenzisa ama-antibiotic futhi isetshenziswa kabanzi ekulimeni kwezinhlanzi. UZhai Qiuling nabanye babonise ukuthi lapho i-tributylglycerol ester engu-100-150 mg/kg ingezwa ekudleni, izinga lokukhuluphala, izinga lokukhula elithile, imisebenzi yama-enzyme ahlukahlukene okugaya ukudla kanye nokuphakama kwe-intestinal villi ngaphambi nangemva kokufakwa kwe-tributylglycerol ester engu-100 mg/kg kungakhushulwa kakhulu; UTang Qifeng nabanye abacwaningi bathole ukuthi ukwengeza i-tributylglycerol ester engu-1.5g/kg ekudleni kungathuthukisa kakhulu ukusebenza kokukhula kwe-Penaeus vannamei, futhi kunciphise kakhulu inani le-pathogenic vibrio emathunjini; UJiang Yingying nabanye. bathole ukuthi ukwengeza i-1g/kg ye-tributyl glyceride ekudleni kungakhuphula kakhulu izinga lokukhuluphala kwe-Allogynogenetic crucian carp, kunciphise i-feed coefficient, futhi kwandise umsebenzi we-superoxide dismutase (SOD) kuma-hepatopancreas; Ezinye izifundo zibonise ukuthi ukwengezwa kwe-1000 mg/kgi-tributyl glycerideUkudla okunempilo kungandisa kakhulu umsebenzi wamathumbu we-superoxide dismutase (SOD) we-Jian carp.
Isikhathi sokuthunyelwe: Jan-05-2023
