Sekungamashumi eminyaka i-butyric acid isetshenziswa embonini yokudla ukuze kuthuthukiswe impilo yamathumbu kanye nokusebenza kwezilwane. Izizukulwane eziningana ezintsha ziye zethulwa ukuze kuthuthukiswe ukuphathwa komkhiqizo kanye nokusebenza kwawo selokhu kwenziwa izivivinyo zokuqala ngawo-1980.

Sekungamashumi eminyaka i-butyric acid isetshenziswa embonini yokudla ukuze kuthuthukiswe impilo yamathumbu kanye nokusebenza kwezilwane. Izizukulwane eziningana ezintsha zethulwe ukuze kuthuthukiswe ukuphathwa komkhiqizo kanye nokusebenza kwawo selokhu kwenziwa izivivinyo zokuqala ngawo-1980..

1. Ukuthuthukiswa kwe-butyric acid njengesithasiselo sokudla

Ama-1980 > I-Butyric Acid esetshenziswa ukuthuthukisa intuthuko yesisu

Ama-1990> usawoti we-butyrin acid osetshenziselwa ukuthuthukisa ukusebenza kwezilwane

Ama-2000> usawoti oqoshiwe wakhiqizwa: ukutholakala kwamathumbu okungcono kanye nephunga elincane

2010s> Kwethulwa i-butyric acid entsha eqinisiwe futhi esebenza kahle kakhulu

Namuhla imakethe ibuswa yi-butyric acid evikelwe kahle. Abakhiqizi bokudla abasebenza nalezi zithasiselo abanazo izinkinga ngezinkinga zephunga futhi umphumela wezithasiselo empilweni yamathumbu nokusebenza kahle kungcono. Inkinga ngemikhiqizo evamile embozwe ukugxila okuphansi kwe-butyric acid. Usawoti ombozwe uvame ukuqukethe i-butyric acid engu-25-30%, okuyinto ephansi kakhulu.

Intuthuko yakamuva ezithasiselweni zokudla ezisekelwe ku-butyric acid ukuthuthukiswa kwe-ProPhorce™ SR: ama-glycerol esters e-butyric acid. Lawa ma-triglyceride e-butyric acid angatholakala ngokwemvelo obisini nasezinyosini. Angumthombo osebenza kahle kakhulu we-butyric acid evikelwe ene-butyric acid efinyelela ku-85%. I-Glycerol inendawo yokuba nama-molecule amathathu e-butyric acid anamathele kuyo ngokusebenzisa lokho okubizwa ngokuthi 'ama-ester bonds'. Lokhu kuxhumana okunamandla kukhona kuwo wonke ama-triglyceride futhi kungaphulwa kuphela ngama-enzyme athile (i-lipase). Esigabeni nasesiswini i-tributyrin ihlala ingashintshi futhi emathunjini lapho i-pancreatic lipase itholakala khona kalula i-butyric acid iyakhishwa.

Indlela yokwenza i-butyric acid ibe yi-esterization ibonakale iyindlela ephumelela kakhulu yokwakha i-butyric acid engenaphunga ekhishwa lapho uyifuna khona: emathunjini.

Umsebenzi we-Tributyrin

1.Ilungisa i-villi yamathumbu amancane ezilwane futhi ivimbele amagciwane ayingozi emathunjini.

2.Kuthuthukisa ukumuncwa kanye nokusetshenziswa kwezakhamzimba.

3.Kunganciphisa uhudo kanye nokucindezeleka kokulunyulwa kwezilwane ezincane.

4.Kukhulisa izinga lokusinda kanye nokwanda kwesisindo sezilwane ezincane nsuku zonke.