Sekungamashumi eminyaka i-butyric acid isetshenziswa embonini yokudla ukuze kuthuthukiswe impilo yamathumbu kanye nokusebenza kwezilwane. Izizukulwane eziningana ezintsha ziye zethulwa ukuze kuthuthukiswe ukuphathwa komkhiqizo kanye nokusebenza kwawo selokhu kwenziwa izivivinyo zokuqala ngawo-1980.

Sekungamashumi eminyaka i-butyric acid isetshenziswa embonini yokudla ukuze kuthuthukiswe impilo yamathumbu kanye nokusebenza kwezilwane. Izizukulwane eziningana ezintsha ziye zethulwa ukuze kuthuthukiswe ukuphathwa komkhiqizo kanye nokusebenza kwawo selokhu kwenziwa izivivinyo zokuqala ngawo-1980.

1 Ukuthuthukiswa kwe-butyric acid njengesithasiselo sokudla

Ama-1980 > I-Butyric Acid esetshenziswa ukuthuthukisa intuthuko yesisu
Ama-1990> usawoti we-butyrin acid osetshenziselwa ukuthuthukisa ukusebenza kwezilwane
Ama-2000> usawoti oqoshiwe wakhiqizwa: ukutholakala kwamathumbu okungcono kanye nephunga elincane
2010s> Kwethulwa i-butyric acid entsha eqinisiwe futhi esebenza kahle kakhulu

Namuhla imakethe ibuswa yi-butyric acid evikelwe kahle. Abakhiqizi bokudla abasebenza nalezi zithasiselo abanazo izinkinga ngezinkinga zephunga futhi umphumela wezithasiselo empilweni yamathumbu nokusebenza kahle kungcono. Inkinga ngemikhiqizo evamile embozwe ukugxila okuphansi kwe-butyric acid. Usawoti ombozwe uvame ukuqukethe i-butyric acid engu-25-30%, okuyinto ephansi kakhulu.

Intuthuko yakamuva ezithasiselweni zokudla ezisekelwe ku-butyric acid ukuthuthukiswa kwe-ProPhorce™ SR: ama-glycerol esters e-butyric acid. Lawa ma-triglyceride e-butyric acid angatholakala ngokwemvelo obisini nasezinyosini. Angumthombo osebenza kahle kakhulu we-butyric acid evikelwe ene-butyric acid efinyelela ku-85%. I-Glycerol inendawo yokuba nama-molecule amathathu e-butyric acid anamathele kuyo ngokusebenzisa lokho okubizwa ngokuthi 'ama-ester bonds'. Lokhu kuxhumana okunamandla kukhona kuwo wonke ama-triglyceride futhi kungaphulwa kuphela ngama-enzyme athile (i-lipase). Esigabeni nasesiswini i-tributyrin ihlala ingashintshi futhi emathunjini lapho i-pancreatic lipase itholakala khona kalula i-butyric acid iyakhishwa.

Indlela yokwenza i-butyric acid ibe yi-esterifying ibonakale iyindlela ephumelela kakhulu yokwakha i-butyric acid engenaphunga ekhishwa lapho uyifuna khona: emathunjini. Umehluko ngosawoti ogcotshwe ubhalwe ku-Fig. 2.

E-ESPN yama-20 ePrague, kwavezwa ucwaningo lokuqhathanisa ngomphumela wezithasiselo ezimbili ezahlukene ezisekelwe ku-butyric acid ezinkukhu. Ukuhlolwa kwenziwa esikhungweni socwaningo lwe-ADAS e-UK ngo-2014. Baqhathanisa usawoti we-sodium ogcotshwe (one-68% coating) ne-ProPhorce™ SR 130 (55% butyric acid). Amachwane angamaduna angu-720 e-Coss308 ahlukaniswe ngamaqembu ama-3, anezibaya ezingu-12 zezinyoni ezingu-20 eqenjini ngalinye. Ukuze kulingiswe izimo zezentengiselwano eduze ngangokunokwenzeka, kwanezelwa udoti ongcolile ngemuva kokuhlolwa kwezifo ezibangelwa amagciwane, amagciwane kanye namagciwane.

Umsebenzi we-Tributyrin

1. Ilungisa i-villi yamathumbu amancane ezilwane futhi ivimbele amagciwane ayingozi emathunjini.

2. Kuthuthukisa ukumuncwa nokusetshenziswa kwezakhamzimba.

3. Kunganciphisa uhudo kanye nokucindezeleka kokulunyulwa kwezilwane ezincane.

4. Kwandisa izinga lokusinda kanye nokwanda kwesisindo nsuku zonke kwezilwane ezincane.