I-Tributyrin ikhiqizwa yinkampani i-Efine bKususelwa ezicini zomzimba kanye nokulawulwa kokudla okunempilo kobuchwepheshe be-mucosa yamathumbu, ucwaningo lohlobo olusha lwemikhiqizo yezempilo yezilwane, lungagcwalisa ngokushesha ukudla okunempilo kwe-mucosa yamathumbu esilwane, lukhuthaze ukuthuthukiswa nokuvuthwa kwe-mucosa yamathumbu, lulungise zonke izinhlobo zokucindezeleka okubangelwa ukulimala kwe-mucosa yamathumbu, luvikele impilo yamathumbu, luqinise umsebenzi wokugaya nokugaya kwamathumbu, lungavimbela ngempumelelo i-necrotizing enteritis futhi luthuthukise ukusebenza kokukhiqiza kwemfuyo nezinkukhu.

Indlela yokusebenza kwe-butyric acid

Iningi lama-fatty acid adingwa yimfuyo kanye nezinkukhu lingatholakala ekudleni (ekufuyeni), kodwa amanye ama-fatty acid amafushane (njenge-butyric acid) awatholakali ngokujwayelekile ekudleni. Ama-fatty acid amafushane, ikakhulukazi i-butyric acid, adlala indima ebalulekile ekugcineni impilo yamathumbu emfuyo kanye nezinkukhu, okuhlanganisa:

1.I-butyric acid iwumthombo wamandla osheshayo wokulungisa ukulimala kwamathumbu emfuyo kanye nezinkukhu, okungabola ngokushesha futhi kukhulule amandla, kukhuthaze ukukhula kwe-chorionic membrane, futhi kuthuthukise umsebenzi wokuvimbela umzimba.

2.I-butyric acid inganciphisa okuqukethwe komoya-mpilo emathunjini, ivimbele ukuphindaphindeka kwamagciwane ayingozi adla umoya-mpilo, futhi ikhuthaze ukwanda kwamagciwane anenzuzo njenge-lactic acid bacteria.

3. I-asidi ye-butyric ingasebenza kuma-molecule esignali asebenzayo amaseli omzimba wamathumbu futhi ithuthukise ukuzivikela komzimba emathunjini.

Imithombo kanye nokuqhathaniswa kwe-butyric acid ekudleni

Inqubo yokuguqulwa kwe-butyric acid ezilwaneni

Ukusebenza kahle kanye nezici

1.Njengophethiloli oyinhloko wokuphefumula wamaseli e-epithelial amathumbu, inganikeza amandla ngokushesha kumaseli e-epithelial amathumbu, ikhuthaze ngempumelelo ukukhula kwamaseli e-mucosal amathumbu, ihlanganyele ekugcinweni nasekulungisweni kwe-mucosal yamathumbu, futhi igcine ubuqotho kanye nokusebenza kwamaseli e-mucosal amathumbu.

2.Ukuphakama kwesisu samathumbu kwanda,kwehle ukujula kwe-crypt , thuthukisaisilinganiso sokuphakama kwe-intestinal villus kuya ekujuleni kwe-crypt , futhithuthukisaisakhiwo sesimo samathumbu amancane.

3.Yehlisa i-pH yamathumbu, vimbela ukukhula kwamagciwane abangela izifo njenge-Escherichia coli, i-Salmonella kanye ne-Clostridium perfringens, ikhuthaza ukwanda kwamagciwane anenzuzo amagciwane e-lactic acid, ilawula ibhalansi yamathumbu ezilwaneni nasezinkukhu.

4.Khuthaza ukukhiqizwa kwama-antibodies kanye nokwanda kwamangqamuzana omzimba e-mucosa yamathumbu, kuthuthukise amandla okulwa nokucindezeleka kanye nokuzivikela komzimba kwemfuyo kanye nezinkukhu, kunciphise ukwenzeka kokuvuvukala kwamathumbu nezinye izifo..

Isithombe 1Imiphumela ye-triglyceride kanye ne-sodium butyrate ehlanganisiwe ekuzuzeni nsuku zonke kwenkukhu ezinezimpaphe ezimhlophe

Imiphumela ibonise ukuthi uma kuqhathaniswa neqembu lokulawula, inzuzo yansuku zonke yenkukhu ezimhlophe ezinezimpaphe yanda kakhulu ngokungezai-tributyrin, futhi umphumela wawungcono kunoweqembu le-sodium butyrate elimboziwe

isithombe 2 Imiphumela ye-triglyceride kanye ne-sodium butyrate eboshiwe ku-microflora yamathumbu ezinkukhu

Imiphumela ibonise ukuthi uma kuqhathaniswa neqembu lokulawula, kwengezwaI-Tributyrin kunganciphisa kakhulu inani le-escherichia coli emathunjini ezinkukhu, futhi kwandise kakhulu inani lamabhaktheriya e-lactic acid, futhi umphumela wawungcono kunoweqembu le-sodium butyrate elihlanganisiwe.

Imiphumela ye-triglyceride kanye ne-sodium butyrate ekukhuleni kanye nezinga lohudo lwengulube encane

Imiphumela ikhombisile ukuthi, njengemiphumela yama-antibiotic, i-triglyceride ingakhuphula kakhulu inzuzo yansuku zonke yama-piglets ngo-11% ~ 14%, yehlise isilinganiso sokudla kwenyama ngo-0.13 ~ 0.15, futhi yehlise kakhulu izinga lohudo lama-piglets, okwakungcono kakhulu kuneqembu le-sodium butyrate.

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