I-Sodium Butyrate noma i-tributyrin'yimuphi okufanele ukhethe'?

Kuyaziwa kakhulu ukuthi i-butyric acid iwumthombo obalulekile wamandla kumaseli e-colonic. Ngaphezu kwalokho, empeleni iwumthombo kaphethiloli okhethwayo futhi inikeza kufika ku-70% wezidingo zawo zamandla eziphelele. Kodwa-ke, kunezinhlobo ezimbili ongakhetha kuzo. Lesi sihloko sinikeza ukuqhathanisa kokubili, okusiza ukuphendula umbuzo othi 'yimuphi okufanele uwukhethe'?

Ukusetshenziswa kwama-butyrate njengesithako sokudla kuye kwafundwa kabanzi futhi kwasetshenziswa kwezolimo zezilwane amashumi eminyaka ambalwa, kwaqala ukusetshenziswa kumathole ukukhuthaza ukukhula kwesisu ngaphambi kokusetshenziswa ezingulubeni nasezinkukhu.

Izithasiselo ze-butyrate zikhombisile ukuthi zithuthukisa ukukhuluphala komzimba (BWG) kanye namazinga okuguqulwa kokudla (FCR), zinciphisa ukufa futhi zinciphise umthelela wezifo ezihlobene namathumbu.

Imithombo evamile ye-butyric acid yokudla kwezilwane iza ngezindlela ezimbili:

1. Njengosawoti (okungukuthi i-Sodium butyrate) noma
2. Ngendlela ye-triglyceride (okungukuthi i-Tributyrin).

Bese kuba umbuzo olandelayo –Ngikhetha ini?Lesi sihloko sinikeza ukuqhathanisa kokubili eceleni.

Inqubo yokukhiqiza

I-sodium butyrate:Kukhiqizwa nge-acid-base reaction ukuze kwakheke usawoti onephuzu eliphezulu lokuncibilika.

I-NaOH+C4 H8 O2=C4 H7 COONa+H2O

(I-Sodium Hydroxide+I-Butyric Acid = I-Sodium Butyrate+Amanzi)

I-Tributyrin:Kukhiqizwa nge-esterification lapho i-3 butyric acid inamathele ku-glycerol ukuze kwakheke i-tributyrin. I-Tributyrin inezinga eliphansi lokuncibilika.

C3H8O3+3C4H8O2= C15 H26 O6+3H2O

(I-Glycerol+Butyric Acid = I-Tributyrin+Amanzi)

Yikuphi okunikeza i-butyric acid eyengeziwe ngekhilogremu ngayinye yomkhiqizo?

KusukelaIthebula 1, siyazi inani le-butyric acid equkethwe emikhiqizweni ehlukene. Kodwa-ke, kufanele futhi sicabangele ukuthi le mikhiqizo ikhipha i-butyric acid emathunjini ngempumelelo kangakanani. Njengoba i-sodium butyrate ingusawoti, izoncibilika kalula emanzini ikhipha i-butyrate, ngakho-ke singacabanga ukuthi i-100% ye-butyrate evela ku-sodium butyrate izokhishwa uma incibilika. Njengoba i-sodium butyrate ihlukana kalula, izinhlobo ezivikelwe (okungukuthi i-micro-encapsulation) ye-sodium butyrate zizosiza ekufinyeleleni ukukhishwa okuqhubekayo kwe-butyrate kuwo wonke amathumbu kuze kube semathunjini amakhulu.

I-Tributyrin empeleni iyi-triacylglyceride (TAG), okuyi-ester etholakala ku-glycerol kanye nama-fatty acid amathathu. I-Tributyrin idinga i-lipase ukuze ikhulule i-butyrate enamathiselwe ku-glycerol. Nakuba i-tributyrin eyodwa iqukethe i-butyrate engu-3, ​​akuwona wonke ama-butyrate angu-3 aqinisekisiwe ukuthi azokhishwa. Lokhu kungenxa yokuthi i-lipase ikhetha kabusha. Ingasusa i-triacylglycerides ku-R1 kanye no-R3, i-R2 kuphela, noma hhayi ngokuqondile. I-Lipase futhi inohlobo oluthile lwe-substrate ngoba i-enzyme ingahlukanisa phakathi kwamaketanga e-acyl anamathiselwe ku-glycerol futhi ihlukanise izinhlobo ezithile ngokuthanda. Njengoba i-tributyrin idinga i-lipase ukuze ikhulule i-butyrate yayo, kungase kube nokuncintisana phakathi kwe-tributyrin namanye ama-TAG e-lipase.

Ingabe i-sodium butyrate kanye ne-tributyrin zithinta ukudla okudliwayo?

I-sodium butyrate inephunga elibi elingathandeki kubantu kodwa elithandwa yizilwane ezincelisayo. I-sodium butyrate ikhiqiza u-3.6-3.8% wamafutha obisi obisini lwebele, ngakho-ke, ingasebenza njengesithako sokudla esibangela imizwa yokusinda yezilwane ezincelisayo (Ithebula 2). Kodwa-ke, ukuqinisekisa ukukhishwa kancane emathunjini, i-sodium butyrate ivame ukumbozwa nge-fat matrix coating (okungukuthi i-Palm stearin). Lokhu kusiza futhi ekunciphiseni iphunga elibi le-sodium butyrate.

Ngakolunye uhlangothi, i-Tributyrin ayinaphunga kodwa inambitheka njenge-astringent (Ithebula 2). Ukwengeza inani elikhulu kungaba nemiphumela emibi ekudleni. I-Tributyrin iyi-molecule eqinile ngokwemvelo engadlula endaweni ephezulu yokugaya ukudla ize iqhekezwe yi-lipase emathunjini. Futhi ayiguquguquki ekushiseni kwegumbi, ngakho ngokuvamile ayimboziwe. I-Tributyrin ivame ukusebenzisa i-silica dioxide engangeni njengethwali layo. I-Silica dioxide inezimbobo futhi ingase ingakhiphi i-tributyrin ngokugcwele ngesikhathi sokugaya ukudla. I-Tributyrin nayo inomfutho ophezulu womoya okwenza ukuthi iguquguquke uma ishiswa. Ngakho-ke, sincoma ukuthi i-tributyrin isetshenziswe ngendlela ehlanganisiwe noma ngendlela evikelwe.