I-sodium butyrate njengesengezo sokuphakelayo sezinkukhu

I-sodium butyrate iyinhlanganisela ye-organic enefomula ye-molecular C4H7O2Na kanye nesisindo samangqamuzana angu-110.0869. Ukubukeka kumhlophe noma kucishe kube yimpushana emhlophe, enephunga elikhethekile le-cheesy rancid kanye nezakhiwo ze-hygroscopic. Ukuminyana kungu-0.96 g/mL (25/4 ℃), indawo encibilikayo ngu-250-253 ℃, futhi inyibilika kalula emanzini ne-ethanol.

I-sodium butyrate, njenge-deacetylase inhibitor, ingakhuphula izinga le-histone acetylation. Ucwaningo luye lwathola ukuthi i-sodium butyrate ingavimbela ukwanda kwamangqamuzana e-tumor, ikhuthaze ukuguga kwamangqamuzana e-tumor kanye ne-apoptosis, okungenzeka ihlotshaniswe nokwanda kwe-histone acetylation nge-sodium butyrate. Futhi i-sodium butyrate isetshenziswe ocwaningweni lomtholampilo ngamathumba. Ingasetshenziswa kabanzi ukwengeza ukudla kwezilwane.

1. Gcina imiphakathi ezuzisayo yamagciwane emgudwini wamathumbu. I-Butyric acid ivimbela ukukhula kwamagciwane ayingozi ngokusebenzisa ulwelwesi lwamangqamuzana, ikhuthaza ukukhula kwamabhaktheriya anenzuzo emgudwini wamathumbu, futhi igcina ibhalansi enhle ku-microbiota yamathumbu;
2. Nikeza ngemithombo yamandla esheshayo kumaseli amathumbu. I-Butyric acid ingamandla athandwayo amaseli amathumbu, futhi i-sodium butyrate imuncwa emgodini wamathumbu. Ngokusebenzisa i-oxidation, inganikeza ngokushesha amandla kumaseli e-epithelial emathunjini;
3. Khuthaza ukwanda nokuvuthwa kwamaseli amathumbu. Umzila wokugaya wezilwane ezisencane awuphelele, ngokukhula okungakavuthwa kwe-intestinal villi encane kanye ne-crypts, kanye nokukhishwa okwanele kwama-enzyme okugaya, okuholela ekutheni ikhono lokumunca izakhi zezilwane ezisencane. Ukuhlola kubonise ukuthi i-sodium butyrate iyi-activator ethuthukisa ukwanda kwe-intestinal villus kanye nokujula kwe-crypt, futhi inganweba indawo yokumunca yamathumbu amakhulu;
4. Umthelela ekusebenzeni kokukhiqizwa kwezilwane. I-sodium butyrate ingakhuphula ukudla okudliwayo, isivuno sokudla, kanye nokuzuza kwesisindo sansuku zonke. Khulisa amazinga empilo yezilwane. Ukunciphisa isifo sohudo kanye nezinga lokufa;
5. Ukuthuthukisa imisebenzi yamasosha omzimba engaqondile futhi ethize;
6. Iphunga elikhethekile linomphumela onamandla ohehayo ezingulubeni ezincane futhi lingasetshenziswa njengesihehe sokudla; Ingangezwa ezinhlotsheni ezihlukene zokuphakelayo ukuze kwandiswe inzuzo yesisindo sosuku, ukudla okudliwayo, izinga lokuguqulwa kokuphakelayo, nokuthuthukisa izinzuzo zezomnotho;
7. Yehlisa ukukhululwa kwe-Ca2+ ye-intracellular. Ukuvimbela i-histone deacetylase (i-HDAC) kanye nokwenza i-apoptosis yeseli;
8. Khuthaza ukuthuthukiswa kwe-mucosa yamathumbu, ukulungisa amangqamuzana e-epithelial e-mucosal, futhi uvule ama-lymphocyte;
9. Yehlisa uhudo ngemva kokulunyulwa kwamaphuphu, nqoba ingcindezi yokulunyulwa, futhi uthuthukise izinga lokusinda kwezingulube.


Isikhathi sokuthumela: Apr-09-2024