I-Betaineiyisakhi esisebenzayo esivame ukusetshenziswa njengesithako sokudla ekudleni kwezilwane, ikakhulukazi njengomnikeli we-methyl. Iyiphi indima engaba khona i-betaine ekudleni kwezinkukhu ezizalelayo futhi iyini imiphumela?

Kugcwaliswe ekudleni okuvela ezithakweni ezingavuthiwe. I-Betaine inganikela ngqo kwelinye lamaqembu ayo e-methyl kumjikelezo we-methylation, kanti i-choline idinga ukuguqulwa kwe-enzyme okuzinyathelo ezimbili ku-mitochondria ngaphakathi kwamaseli esibindi. Ngakho-ke, i-betaine izosebenza kahle kakhulu njengomnikeli we-methyl uma kuqhathaniswa ne-choline. Ama-molecule e-betaine engeziwe ayakwazi ukungena emaseli ukuze alondoloze ubuqotho bamaseli (amathumbu), isakhiwo samaprotheni, kanye ne-homeostasis. Ukugcina ubuqotho bamaseli amathumbu kanye nempilo yamathumbu kuyisisekelo sokuthuthukisa ukuphila, ukugaya izakhamzimba kanye nokukhiqizwa.

Isivivinyo sezentengiselwano

Ukuze kuqinisekiswe imiphumela emihle ye-betaine uma kuqhathaniswa ne-choline, kwenziwa ucwaningo lwezentengiselwano lwase-US oluqhutshwa ngabasebenzi ababili phakathi nesikhathi sokukhiqizwa kwesendlalelo. Emasontweni angama-21 ubudala, izingqimba ezinsundu ze-Lohman ohlelweni olungenazo izikheji zanikezwa ukudla okulawulayo okwakuhlanganisa i-500 ppm ye-60% choline chloride noma ukudla okuthatha indawo yale choline nge-348 ppm ye-Excential Beta-Key (betaine hydrochloride 95%). Ku-348 ppm, ExcentialUkhiye we-Betaithatha indawo yokulingana okungu-100% kwe-500 ppm 60% choline chloride, okusho ukuthi kokubili ukudla kokulawula nokuhlola kunikeze inani elifanayo lama-molecule labanikeli be-methyl, njenge-choline noma i-betaine, ngokulandelana.

Idatha yokukhiqiza ikhombisile ukuthi emavikini angu-59 ubudala noma, emavikini angu-38 kusukela ekuqaleni kokuhlolwa, amaqanda ajwayelekile ngenkukhu ngayinye akhuliswe ngamaqanda angu-3.4. Ngokombono wokukhiqiza, amaqanda engeziwe angu-60,396 akhiqizwa njengoba kubonwe ku-Umfanekiso 1.

Isithombe 1 – Ukukhiqizwa kwamaqanda okuqoqana kusukela emavikini angu-21-59 ubudala.

Ngaphandle koshintsho lokuphatha ngaphandle kokwengeza i-betaine, emakethe yase-US ukwengezwa kwe-Excential Beta-Key ku-348 ppm kanye nokufaka esikhundleni se-choline chloride eyengeziwe kubalwe ukuthi kuholele ku-ROI okungenani engu-6:1 ekukhiqizweni kwezinyoni ezingu-20,000.

Ithonya ekuswakameni nasekufeni kwemfucuza
Esinye isici esibalulekile ekuphathweni kwezinkukhu umswakama wendle. Ukugaya ukudla okuthuthukisiwe kanye nokukhula kwamaseli amathumbu kuye kwahlotshaniswa ne-betaine eyengeziwe. Lezi zici zibangelwa ukugcinwa kwamanzi okungcono kwesilwane futhi ngaleyo ndlela kulawulwa indle.

Ukwanda komswakama wemfucuza kunciphisa ikhwalithi yemfucuza futhi kungaholela ezinkingeni zokukhiqiza okuhlanganisa kodwa kungagcini nje ngamazinga aphezulu e-ammonia, ukwanda kwezinkinga ngekhwalithi yezinyawo kanye namaqanda angcolile. Ukuthuthukisa ukugayeka kwezakhamzimba ngokufaka i-betaine nakho kungathinta umswakama wemfucuza. Ngesikhathi sokuhlolwa kwezentengiselwano, amasampula emfucuza kuzo zombili izindlu aqoqwe emavikini angu-35, 45 kanye no-55. Nakuba njengoba kuboniswe kuThebula 1, umswakama wemfucuza wawuphethwe kahle, ukwengeza i-betaine hydrochloride kunciphisa kakhulu umswakama ngaphezu kuka-3%. Ukusebenzisa i-betaine hydrochloride esikhundleni se-choline chloride, ikakhulukazi ezindlini ezidinga ukulawula umswakama kungaba ithuluzi eliwusizo kubakhiqizi.

Ukufa nokuphila kahle nakho kuyizimpawu ezibalulekile zomhlambi ophumelelayo. Njengoba kuboniswe kuThebula 2, i-betaine yehlise ukufa komhlambi ngamaphesenti afinyelela ku-1.98.

I-Betaine iyithuluzi eliwusizo kubakhiqizi

I-Excential Beta-Key ingathatha indawo ye-100% ye-choline chloride eyengeziwe ezingqimbeni. Ngenxa yokuthi ukusebenza kahle kwe-betaine njenge-methyldonor kuphakeme uma kuqhathaniswa ne-choline, insalela ye-betaine etholakalayo ezingqimbeni ithuthukisa ukusebenza kahle kwamaseli futhi isiza ukuthuthukisa ukusebenza kahle. Ngokunciphisa ukufa kanye nomswakama wendle, i-betaine iyithuluzi eliwusizo kubakhiqizi lokuthuthukisa ukuphila kahle kwezingqimba. Ngokwandisa ukusebenza kahle kwe-osmoregulation, insalela ye-betaine ingase inciphise ukuwohloka kwamaprotheni eqandeni, ngakho-ke i-betaine ithuthukisa ikhwalithi yamaqanda futhi inwebe ubusha.