I-DMPT, INOMBOLO YE-CAS: 4337-33-1. Okunconointo ekhangayo emanzinimanje!

I-DMPTeyaziwa ngokuthi i-dimethyl-β-propiothetin, ikhona kakhulu ezitshalweni zasolwandle kanye ne-halophytic ephakeme. I-DMPT inomphumela okhuthazayo kumetabolism yokudla okunomsoco kwezilwane ezincelisayo, izinkukhu, nezilwane zasemanzini (izinhlanzi nezimfanzi). I-DMPT into enomphumela onamandla wokuyenga ezilwaneni zasemanzini phakathi kwazo zonke izinhlanganisela ezaziwayo eziqukethe (CH) kanye nama-S-groups.

1. Umthombo we-DMPT

I-dimethyl sulfide (DMS) ekhiqizwa yi-Polysipho - nia fastigata iphuma kakhuluI-DMPT, ephinde ibe ngumnikezeli we-methyl osebenzayo ku-algae, futhi umlawuli oyinhloko we-osmotic we-algae kanye nesitshalo se-mudflat i-Spartina angelica nayo i-DMPT. Okuqukethwe kwe-DMPT kuyahlukahluka phakathi kwezinhlobo ezahlukene zezimila zasolwandle, futhi okuqukethwe kohlobo olufanayo lokhula lwasolwandle nakho kuyahlukahluka ngezinkathi zonyaka ezahlukene. I-DMPT ingasheshisa kakhulu ukudla nokukhula kwezinhlanzi zasemanzini ahlanzekile ahlukahlukene. Umphumela wokudla we-DMPT uhlukile kwezinye izinto ezifana ne-L-amino acid noma ama-nucleotide, futhi unemiphumela ekhuthaza ukudla nokukhula cishe kuzo zonke izilwane zasemanzini.

2.1 Ama-Ligands Aphumelelayo Njengezamukeli Zokunambitha

Ucwaningo lwama-receptors ezithweni zezinzwa zamakhemikhali ezinhlanzi ezingase zihlanganyele (CH) S-groups namanje alunalutho. Kusukela emiphumeleni ekhona yokuhlola yokuziphatha, kungahlaziywa ukuthi izinhlanzi nakanjani zinama-taste receptors ezingase zihlanganyele nezinhlanganisela eziphansi zesisindo samangqamuzana aqukethe (CH), N -, kanye (CH2) 2S - amaqembu.

2.2 Njengomnikeli we-methyl

I-(CH) kanye nama-S-amaqembu ku-I-DMPTI-molecule iyimithombo yamaqembu e-methyl adingekayo ukuze kusetshenziswe ukudla okunomsoco wezilwane. Kunezinhlobo ezimbili zama-methyltransferase (EC2.1.1.3 kanye ne-EC2.1.1.5) esibindini sesilwane ezisetshenziswa izilwane (CH) kanye ne-S.

Kutholwe ukuthi ukugcwala kwe-DMPT kanye nezinga lokukhishwa kwe-DMS kumaseli okhula lwasolwandle liyenyuka ngokwanda kosawoti endaweni yesiko lokhula lwasolwandle olukhulisiwe (Hymenonas carterae).

I-DMPTinothiswe emangqamuzaneni ezinhlobo eziningi ze-phytoplankton, algae, nezinhlobo ze-symbiotic mollusk ezifana nezimbaza namakhorali, kanye nakuma-krill nezinhlanzi. Iida et al. (1986) ukuqinisekisile ukuthi okuqukethwe kwe-DMPT kanye nokukhiqizwa kwe-DMS ezinhlanzini kuhlotshaniswa kahle nokuqukethwe kwe-DMPT ekudleni kwazo, okubonisa ukuthi irayisi le-DMPT ezilwaneni livela ku-bait futhi lingena emzimbeni wesilwane somuntu ngochungechunge lokudla ezindaweni zasolwandle. Ulwelwe lungahlanganisa i-DMPT futhi lubuthelele emazingeni aphezulu (3-5 mmol/L) emzimbeni. I-DMPT ezinhlanzini nasezimbazaneni iseduze namazinga azo ekudleni, futhi ukugxila kwe-DMPT kukhombisa ukwehla kokulandelana kwe-algae (1 mmol/L), i-mollusks (0.1 mmol/L), nenhlanzi (0.01 mmol/L).

I-Physiological Mechanism yeI-DMPTIsenzo

Eminyakeni yamuva nje, ucwaningo luye lwathola ukuthi i-DMPT inomphumela okhuthazayo ekuziphatheni kokudla nasekukhuleni kwezinhlanzi ezihlukahlukene zasolwandle namanzi ahlanzekile, ama-crustaceans, ne-shellfish, ezingathuthukisa amandla abo okulwa nokucindezeleka nokuzivocavoca, futhi zengeze ama-enzyme abalulekile weqembu eliphansi lokuhlushwa i-methyl ekudleni. Ukusebenzisa isibindi se-sea bream njengento yokuhlola kanye nezinhlanganisela ezihlukahlukene eziqukethe (CH) kanye nama-S - amaqembu njengama-substrates, kutholakale ukuthi u-E C.2.1.1.3 no-E Umsebenzi we-enzyme uphakeme kakhulu uma i-DMPT isetshenziswa njenge-substrate.

3. Imiphumela yokudla okunempilo kwe-DMPT ezilwaneni zasemanzini

Izinhlanganisela zezinto eziphilayo ezinesisindo esiphansi se-molecular (CH) kanye nama-S-groups asetshenziselwa ukuziphatha okuluma kanye nokuhlolwa kwe-electrophysiological emanzini olwandle nezinhlanzi zasemanzini ahlanzekile. Kutholwe ukuthi i-DMPT inomphumela okhuthazayo oqine kakhulu ekulumeni kwezinhlobo ezintathu zezinhlanzi, okuhlanganisa i-tuna yamanzi ahlanzekile, i-carp, ne-black crucian carp (Carassius auratus cuviera). Kuphinde kwakhuthaza kakhulu ukuziphatha kokuphakela kwesikali sangempela samanzi olwandle (i-Pagrus enkulu) nezikali ezinhlanu (Seriola quinquera diata).

Hlanganisa i-DMPT nezinye izinhlanganisela eziqukethe isulfure ekuhlanganiseni okungu-1.0mmol/L. ekudleni okuhlukahlukene kokuhlola, futhi esikhundleni seqembu lokulawula ngamanzi a-distilled ukuqhuba ukuhlolwa kwempendulo yokondla ku-crucian carp. Imiphumela yabonisa ukuthi emaqenjini amane okuqala okuhlola, iqembu le-DMPT linesilinganiso se-126 ephakeme kakhulu yokuluma kuneqembu lokulawula; Esivivinyweni sesibili seqembu le-5, iqembu le-DMPT laliphakeme izikhathi ezingu-262.6 kuneqembu lokulawula. Ekuhlolweni okuqhathaniswa ne-glutamine, kwatholakala ukuthi ekugxilweni kuka-1.0mmol/L.