Isengezo sokudla: i-Tributyrin

Okuqukethwe: 95%, 90%

I-Tributyrin njengesengezo sokudla ukuze kulethwe ngcono impilo yamathumbu ezinkukhu.

Ukuyeka ukusebenzisa ama-antibiotic njengezikhuthazi zokukhula ezindleleni zokupheka ukudla kwezinkukhu kwandisa intshisekelo yamasu okudla ahlukile, kokubili ukwandisa ukusebenza kahle kwezinkukhu kanye nokuvikela ezinkingeni zezifo.

Ukunciphisa ubuhlungu be-dysbacteriosis
Ukuze kuhlolwe izimo ze-dysbacteriosis, izithasiselo zokudla ezifana nama-probiotic nama-prebiotic ziyangezwa ukuze zithonye ukukhiqizwa kwama-SCFA, ikakhulukazi i-butyric acid edlala indima ebalulekile ekuvikeleni ubuqotho bomgudu wamathumbu. I-butyric acid iyi-SCFA eyenzeka ngokwemvelo enemiphumela eminingi ewusizo efana nomphumela wayo wokulwa nokuvuvukala, ithonya layo lokusheshisa inqubo yokulungisa amathumbu kanye nokukhuthaza ukuthuthukiswa kwe-gut villi. Kukhona indlela ehlukile i-butyric acid esebenza ngayo ngendlela yokuvimbela ukutheleleka, okungukuthi ukwenziwa kwe-Host Defense Peptides (HDPs), okwaziwa nangokuthi ama-anti-microbial peptides, okuyizingxenye ezibalulekile zokuzivikela komzimba okungokwemvelo. Zinomsebenzi we-broad-spectrum anti-microbial ngokumelene namagciwane, isikhunta, ama-parasites kanye namagciwane ambozwe okunzima kakhulu ukuthi amagciwane athuthukise ukumelana nawo. Ama-Defensins (AvBD9 & AvBD14) kanye nama-Cathelicidins yimindeni emibili emikhulu yama-HDP (Goitsuka et al.; Lynn et al.; Ganz et al.) atholakala ezinkukhu ezikhuliswa yi-butyric acid supplementation. Ocwaningweni olwenziwe nguSunkara et. al. Ukuphathwa kwe-butyric acid ngaphandle kubangela ukwanda okuphawulekayo kokubonakaliswa kwezakhi zofuzo ze-HDP futhi ngaleyo ndlela kuthuthukisa ikhono lokumelana nezifo ezinkukhu. Ngokuthakazelisayo, ama-LCFA aphansi futhi aphakathi nendawo.

Izinzuzo zezempilo ze-Tributyrin
I-Tributyrin iyisandulela se-butyric acid evumela ama-molecule amaningi e-butyric acid ukuthi alethwe emathunjini amancane ngqo ngenxa yendlela yokwenziwa kwe-esterification. Ngaleyo ndlela, amazinga aphezulu ngokuphindwe kabili kuya kathathu kunemikhiqizo evamile embozwe nge-esterification. I-esterification ivumela ama-molecule amathathu e-butyric acid ukuthi aboshelwe ku-glycerol engaphulwa kuphela yi-pancreatic lipase endogenous.
ULi nabanye basungula ucwaningo lwe-immunological ukuthola imiphumela emihle ye-tributyrin kuma-cytokine akhuthaza ukuvuvukala kuma-broilers abhekene ne-LPS (lipopolysaccharide). Ukusetshenziswa kwe-LPS kuyaziwa kabanzi ukuthi kubangela ukuvuvukala ezifundweni ezinjengalezi ngoba kuvuselela izimpawu zokuvuvukala njenge-IL (Interleukins). Ezinsukwini ezingama-22, 24, kanye no-26 zesilingo, ama-broilers aphonselwa inselelo ngokuphathwa ngaphakathi kwe-peritoneal kwe-500 μg/kg BW LPS noma i-saline. Ukwengezwa kwe-tributyrin yokudla okungu-500 mg/kg kwavimbela ukwanda kwe-IL-1β kanye ne-IL-6 okubonisa ukuthi ukwengezwa kwayo kuyakwazi ukunciphisa ukukhishwa kwama-cytokines akhuthaza ukuvuvukala futhi ngaleyo ndlela kunciphise ukuvuvukala kwamathumbu.

Isifinyezo
Njengoba ukusetshenziswa okulinganiselwe noma ukuvinjelwa ngokuphelele kwezikhuthazi zokukhula kwama-antibiotic ezithile njengezithasiselo zokudla, amasu amasha okuthuthukisa nokuvikela impilo yezilwane zasemapulazini kumele ahlolwe. Ubuqotho bamathumbu busebenza njengesixhumi esibalulekile phakathi kwezinto zokusetshenziswa zokudla ezibizayo kanye nokukhuthazwa kokukhula kwenkukhu. I-butyric acid ikakhulukazi ibhekwa njengesikhuthazi esinamandla sempilo yamathumbu esivele sisetshenziswa ekudleni kwezilwane iminyaka engaphezu kwengu-20. I-Tributyrind iletha i-butyric acid emathunjini amancane futhi iyasebenza kakhulu ekuthinteni impilo yamathumbu ngokusheshisa inqubo yokulungisa amathumbu, ikhuthaza ukuthuthukiswa kwe-villi efanele futhi iguqule ukusabela komzimba endleleni yamathumbu.

Manje njengoba imithi yokulwa namagciwane isiqedwa, i-butyric acid iyithuluzi elihle lokusekela imboni ukunciphisa umthelela omubi we-dysbacteriosis ovele ngenxa yalolu shintsho.