Kudingeka ezinye izindlela zokwelapha ngaphandle kwama-antibiotic ngenxa yokuvinjelwa kokusetshenziswa kwale mithi njengabagqugquzeli bokukhula ekukhiqizweni kokudla kwezilwane. Kubonakala sengathi i-Tributyrin idlala indima ekuthuthukiseni ukusebenza kokukhula ezingulubeni, yize inezinga elihlukahlukene lokusebenza kahle.

Kuze kube manje, kuncane kakhulu okwaziwayo ngemiphumela yako ekwakhekeni kwe-gut microbiota. Kulolu cwaningo, sihlole izinguquko ze-gut microbiota zezingulube ezincane ezithola, ngesikhathi zilunyulwa, i-0.2% tributyrin engezwe ekudleni kwazo okuyisisekelo.

Iqembu le-Tributyrin lalinamandla athuthukisiwe okusebenzisa amandla kanye nekhono elinciphile lokusebenzisa ama-carbohydrate. Ekuphetheni, imiphumela yethu ibonise ukuthi i-tributyrin ingakhuthaza izinguquko emiphakathini yamagciwane emathunjini, okungaba negalelo ekuthuthukiseni ukusebenza kwezilwane ngemva kokulunyulwa.

Imiphumela ye-Tributyrin ekushintsheni kwe-Gut Microbiota okuhlobene nokusebenza kwezingulube ezilunyulwayo

Amapharamitha Omkhiqizo

I-Tributyrin (ebizwa nangokuthi i-Glyceryl tributyrate; i-Glycerol tributyrate; i-Glycery tributyrate; i-propane-1,2,3-triyl tributanoate), uhlobo lwe-ester yama-fatty acid e-short chain.

I-CAS RN: 60-01-5

Inombolo ye-EINECS: 200-451-5

Ifomula: C15H26O6

I-FW: 302.36

Ukubukeka: Lumhlophe kuya kophuzi uketshezi olunamafutha olunephunga elimnandi kancane.

Ukuncibilika: kuncibilika ku-ethanol, i-chloroform kanye ne-ether, akuncibiliki emanzini (0.010%).

Impilo Yeshelufu: Izinyanga ezingama-24

Iphakheji: 25KG/ Isikhwama

Isitoreji: Kuvaliwe ezindaweni ezomile nezinomoya

I-Tributyriniyi-triglyceride equkethe ama-molecule amathathu e-butyrate ahlanganiswe ne-glycerol, okwandisa amazinga e-butyrate ngemva kokuncishiswa yi-pancreatic lipases.

Izici ze-Tributyrin
Isizukulwane esisha se-butyrate-glycerol ester ye-butyric acid.
Isisu esidlulayo ngokuphelele.
Ukuhambisa ama-asidi e-butyric emathunjini amancane, akudingeki ukuthi ambozwe.
Ngokwemvelo kutholakala obisini nasojuni.

Ukuqhathanisa Phakathi kwe-Tributyrin ne-Butyrate Salt

Isigamu sokuphila se-butyric acid singamaminithi angu-6. I-butyrate kunzima ukuyifinyelela kwezinye izicubu nezitho ezingaphandle kwamathumbu uma inikezwa ngesimo se-butyric acid noma i-butyrate. Kodwa-ke, isigamu sokuphila se-tributyrin singamaminithi angu-40, kanti ukuhlushwa kwe-butyrate egazini kungagcinwa ngaphezu kuka-0.1mM amahora angu-0.5-4 ngomlomo.

Indlela kanye nezici

Umhlinzeki Wamandla

Njengoba kwaziwa kakhulu, i-butyric acid iyi-fatty acid emfushane engumthombo wamandla oyinhloko wamaseli e-epithelial emathunjini. Amandla angaphezu kuka-70% okukhula kwamaseli e-epithelial emathunjini anikezwa yi-butyric acid. Kodwa-ke, i-tributyrin inikeza inani eliphakeme kakhulu le-butyric acid elikhipha amathumbu uma kuqhathaniswa neminye imikhiqizo ye-butyrate.

Ukuvikelwa Kwamathumbu

►I-Tributyrin ikhuthaza ukwanda nokwehlukaniswa kwamaseli e-epithelial e-mucosal yamathumbu, ilungisa i-mucosa eyonakele, futhi yandisa indawo engaphezulu ukuze imunce izakhamzimba.

►I-Tributyrin ikhuthaza ukuvezwa kwamaprotheni e-tight junction emathunjini, igcina ukuhlangana okuqinile phakathi kwamaseli, ivimbela ama-macromolecule afana namabhaktheriya nobuthi ukuthi bungangeni emzimbeni, futhi igcina umsebenzi wokuvimbela umzimba wamathumbu.

►I-Tributyrin ikhuthaza ukukhiqizwa kwe-mucin (Muc) futhi iqinisa umsebenzi wokuvimbela amakhemikhali emathunjini.

Izinga Lokusinda Lithuthukisiwe

I-Tributyrin ingakhuthaza ukwakheka kwe-hemoglobin, ithuthukise ikhono lokuthwala umoya-mpilo, iqinise uhlelo lokusekela impilo lwangaphakathi, futhi ingathuthukisa ukusebenza kwe-mitochondria futhi ikhuthaze ukwakheka kwe-ATP, into yamandla eqhuba umsebenzi wokuphila, ukuze ithuthukise izinga lokusinda noma izilwane.

Okulwa Nokuvuvukala kanye Ne-Antibacteria

►Ngokuvimbela umsebenzi we-NF-Kb, TNF-α kanye ne-TLR, i-Tributyrin inganciphisa umonakalo wokuvuvukala.

►I-Tributyrin ikhuthaza ukuvezwa kwama-peptide okuzivikela angokwemvelo, angamelana ne-pathogen kanye negciwane kabanzi.