I-Guanylacetic acid, eyaziwa nangokuthi i-guanylacetic acid, iyi-analogue ye-amino acid eyakhiwe nge-glycine ne-L-lysine.

I-Guanylacetic acid ingahlanganisa i-creatine ngaphansi kwe-catalysis yama-enzyme futhi iwukuphela kwemfuneko yokwakhiwa kwe-creatine. I-Creatine yaziwa njengesilondolozi samandla, futhi umsebenzi wayo oyinhloko ukwakha i-phosphorylated creatine ngaphansi kwesenzo se-creatine kinase.

Bamba iqhaza ohambweni lwe-adenosineumjikelezo we-hosphate (ATP). Lapho amandla e-ATP enganele, i-phosphocreatine idlulisela ngokushesha iqembu le-phosphate ku-adenosine diphosphate ngokusebenzisa i-creatine kinase futhi ilibuyisele ku-adenosine triphosphate.

 

Isicelo kuma-ruminants:

Ukwengeza u-0.12%, 0.08%, kanye no-0.04% we-guanylacetic acid ekudleni kwezimvu eziyi-120 eziphakelwa i-Tan ezinesisindo esingamakhilogremu angu-20, ngokulandelana, kubonise ukuthi ukungezwa kwe-0.12% no-0.08% we-guanylacetic acid kwandise kakhulu ukuzuza kwesisindo sansuku zonke, okuqukethwe kwamafutha e-intramuscular, kwehla kakhulu amaprotheni e-carcascular.

 

Ukwengezwa kwe-0.08%i-guanylacetic acidinyuke iphesenti lenyama yonke ngo-9.77%. Ngokusebenzisa indlela yokukhiqiza igesi ye-in vitro, umphumela wokwengeza amazinga ahlukene e-guanylacetic acid ku-rumen yezinkomo eziphuzi wacwaningwa. Kwatholakala ukuthi ukungezwa kwe-0.4% ye-guanylacetic acid kwandisa kakhulu ukukhiqizwa kwegesi, futhi ukugxila kwe-ammonia nitrogen kuqala kwanda kwase kuncipha.

Ngakho-ke, kungacatshangwa ukuthi ukwengeza i-guanylacetic acid ekudleni kwansuku zonke kungathuthukisa indawo yangaphakathi ye-rumen kanye nemodi yokuvubela yezinkomo eziphuzi.

Isicelo ezinkukhu:

Ukwengeza u-800 mg/kg, 1600 mg/kg, 4000 mg/kg, kanye no-8000 mg/kg we-guanylacetic acid ekudleni kwansuku zonke kwama-broilers kubonise ukuthi ukungeza u-800-4000 mg/kg we-guanylacetic acid ekuphakeleni kwenyusa kakhulu inzuzo yansuku zonke yesisindo sama-broilers, kwehlisa isilinganiso sesisindo sezinsuku ezi-2 kuya kwezi-2 ubudala. Ukwengeza u-8000 mg/kg we-guanylacetic acid izinkomba ezithuthukisiwe ze-biochemical serum ezifana ne-urea nitrogen, izinkomba zesimiso segazi, kanye nesamba se-bilirubin Akubanga khona umthelela obalulekile ezinkomba ezinkulu zesitho, okubonisa ukuthi ukungeza u-8000 mg/kg we-guanylacetic acid ekudleni kwansuku zonke kwama-broilers kuyabekezeleleka.

Ukwengeza u-200 mg/kg, 400 mg/kg, 600 mg/kg, kanye no-800 mg/kg we-guanylacetic acid ekudleni kwe-broiler kubonise ukukhuphuka okuphawulekayo kwesilinganiso sesisindo sosuku uma kuqhathaniswa neqembu lokulawula. Imiphumela emihle kakhulu ifinyelelwe lapho amazinga okungezwa angu-600 kanye nama-800 mg/kg.

Ukuze kufundwe umphumela we-guanylacetic acid eqophelweni lesidoda kumaqhude, kwakhethwa amaqhude angama-20 anamasonto angama-28 ubudala ukuze adlise ukudla okuqukethe u-0%, 0.06%, 0.12%, kanye no-0.18% we-guanylacetic acid. Imiphumela yocwaningo ithole ukuthi ukwengeza u-0.12% we-guanylacetic acid ekudleni kwandisa kakhulu inani lesidoda, ukugxila kwesidoda, nomsebenzi wesidoda kumaqhude, okubonisa ukuthi ukwengeza i-guanylacetic acid ekudleni kungathuthukisa ngempumelelo ikhwalithi yesidoda. Engeza u-0.0314%, 0.0628%, 0.0942%, no-0.1256% we-guanylacetic acid ekudleni kwansuku zonke kwama-broilers, bese usetha amaqembu amabili okulawula (iqembu lokulawula 1 liwukudla okusekelwe ezitshalweni ngaphandle kwento engeziwe, futhi iqembu lokulawula 2 liwukudla okunesidlo sezinhlanzi). Amaqembu angenhla ayisithupha okudla kwansuku zonke anezinga elifanayo lamandla namaminerali.

Imiphumela yokuhlola ibonisa ukuthi amazinga okuzuza kwesisindo samaqembu amane ane-guanylacetic acid engeziwe kanye neqembu lokulawula i-2 liphakeme kuneqembu lokulawula i-1, Iqembu lokulawula i-2 libe nomphumela omuhle kakhulu wokuzuza isisindo, kulandelwa iqembu le-0.0942% le-guanylacetic acid; Iqembu lokulawula 2 libe nesilinganiso esihle kakhulu sesisindo sempahla, lilandelwa yiqembu le-guanylacetic acid elingu-0.1256%.

Isicelo ezinkukhu:

Ukwengeza 800 mg/kg, 1600 mg/kg, 4000 mg/kg, kanye 8000 mg/kgi-guanylacetic acidekudleni kwansuku zonke kwama-broilers kubonise ukuthi ukwengeza u-800-4000 mg/kg we-guanylacetic acid ekudleni kwandisa kakhulu isisindo sansuku zonke sama-broilers, kunciphisa isilinganiso sokuphakelayo nesisindo sama-broilers ezinsukwini ezingama-22-42 ubudala. Ukwengeza u-8000 mg/kg we-guanylacetic acid izinkomba ezithuthukisiwe ze-biochemical serum ezifana ne-urea nitrogen, izinkomba zesimiso segazi, kanye nesamba se-bilirubin Akubanga khona umthelela obalulekile ezinkomba ezinkulu zesitho, okubonisa ukuthi ukungeza u-8000 mg/kg we-guanylacetic acid ekudleni kwansuku zonke kwama-broilers kuyabekezeleleka. Ukwengeza u-200 mg/kg, 400 mg/kg, 600 mg/kg, kanye no-800 mg/kg we-guanylacetic acid ekudleni kwe-broiler kubonise ukukhuphuka okuphawulekayo kwesilinganiso sesisindo sosuku uma kuqhathaniswa neqembu lokulawula. Imiphumela emihle kakhulu ifinyelelwe lapho amazinga okungezwa angu-600 kanye nama-800 mg/kg.

Ukuze kufundwe umphumela we-guanylacetic acid eqophelweni lesidoda kumaqhude, kwakhethwa amaqhude angama-20 anamasonto angama-28 ubudala ukuze adlise ukudla okuqukethe u-0%, 0.06%, 0.12%, kanye no-0.18% we-guanylacetic acid. Imiphumela yocwaningo ithole ukuthi ukwengeza u-0.12% we-guanylacetic acid ekudleni kwandisa kakhulu inani lesidoda, ukugxila kwesidoda, nomsebenzi wesidoda kumaqhude, okubonisa ukuthi ukwengeza i-guanylacetic acid ekudleni kungathuthukisa ngempumelelo ikhwalithi yesidoda. Engeza u-0.0314%, 0.0628%, 0.0942%, no-0.1256% we-guanylacetic acid ekudleni kwansuku zonke kwama-broilers, bese usetha amaqembu amabili okulawula (iqembu lokulawula 1 liwukudla okusekelwe ezitshalweni ngaphandle kwento engeziwe, futhi iqembu lokulawula 2 liwukudla okunesidlo sezinhlanzi). Amaqembu angenhla ayisithupha okudla kwansuku zonke anezinga elifanayo lamandla namaminerali. Imiphumela yokuhlola ibonisa ukuthi amazinga okuzuza kwesisindo samaqembu amane ane-guanylacetic acid angeziwe futhi iqembu lokulawula i-2 liphakeme kuneqembu lokulawula i-1, Iqembu lokulawula i-2 libe nomphumela omuhle kakhulu wokuzuza isisindo, kulandelwa i-0.0942%i-guanylacetic acidiqembu; Iqembu lokulawula 2 libe nesilinganiso esihle kakhulu sesisindo sempahla, lilandelwa yiqembu le-guanylacetic acid elingu-0.1256%.