Imikhiqizo ehlukahlukene yama-antibiotic ekukhiqizweni kwezinkukhu iyavinjelwa kancane kancane emhlabeni wonke ngenxa yezinkinga ezimbi okuhlanganisa izinsalela zama-antibiotic kanye nokumelana nama-antibiotic. I-Tributyrin yayiyindlela engcono kune-antibiotic. Imiphumela yalolu cwaningo ibonise ukuthi i-tributyrin ingathuthukisa ukusebenza kokukhula ngokushintsha izinkomba ze-biochemical yegazi kanye nokwakheka kwe-microflora ye-cecal yama-broilers anezimpaphe eziphuzi. Ngokwazi kwethu, zimbalwa izifundo eziphenye imiphumela ye-tributyrin kuma-microbiota amathumbu kanye nobudlelwano bayo nokusebenza kokukhula kuma-broilers. Lokhu kuzohlinzeka ngesisekelo sesayensi sokusetshenziswa kwe-tributyrin ekufuyweni kwezilwane kule nkathi yangemva kwama-antibiotic.

I-asidi ye-butyric ikhiqizwa ngaphakathi kwe-lumen yamathumbu esilwane ngokubiliswa kwamagciwane kwama-carbohydrate angagayiwe kanye namaprotheni angaphandle. Ama-90% ale asidi ye-butyric aguqulwa ngamaseli e-cecal epithelial noma ama-colonocytes ukuze anikeze imiphumela eminingi enenzuzo empilweni yamathumbu.

Kodwa-ke, i-free butyric acid inephunga elibi futhi kunzima ukuyiphatha lapho isebenza. Ngaphezu kwalokho, i-free butyric acid iboniswe ukuthi imuncwa kakhulu emgodini wesisu ongaphezulu, okwenza iningi layo lingafinyeleli emathunjini amakhulu, lapho i-butyric acid izosebenza khona kakhulu.

Ngakho-ke, i-butyrate ye-sodium salt ethengiswayo yakhiwe ukuze kube lula ukuyiphatha nokuvimbela ukukhishwa kwe-butyric acid endleleni ephezulu yesisu namathumbu.

Kodwa i-tributyrin iqukethe i-butyric acid kanye ne-mono-butyrin kanti engxenyeni ephezulu yesisu, i-tributyrin ifakwa i-butyric acid kanye ne-α-mono-butyrin kodwa engxenyeni engezansi yesisu, i-molecule enkulu izoba yi-α-monobutyrin enikeza amandla engeziwe, ukukhulisa ukukhula kwemisipha nokukhuthaza ukuthuthukiswa kwama-capillary ukuze kuthuthwe izakhamzimba ezingcono.

Kunezinkinga eziningana ezihlobene nempilo yamathumbu ezinkukhu ezihlanganisa:

• isifo sohudo
• i-malabsorption syndrome
• i-coccidiosis
• i-necrotic enteritis

Ukwengezwa kwe-tributyrin kuye kwasetshenziswa kabanzi ukulwa nezinkinga zamathumbu, futhi ekugcineni kuthuthukise impilo yamathumbu enkukhu.

Ezinkukhuni zenkukhu ezibekwe eceleni, iyakwazi ukuthuthukisa ukumuncwa kwe-calcium ikakhulukazi ezinkukhuni ezindala ezibeka amaqanda futhi ithuthukise ikhwalithi yamagobolondo amaqanda.

Emazinyaneni omntwana ukuguquka kokumunca ubisi kuyisikhathi esibucayi ngenxa yokucindezeleka okukhulu okubangelwa ukushintsha kusuka koketshezi kuya kokudla okuqinile, ukushintsha indawo, kanye nokuxubana nezilwane ezintsha ezifuywayo.

Esivivinyweni sakamuva sezingulube ezincane esizenzile eRivalea, kukhonjiswe ngokusobala ukuthi ukwengeza ukudla kwe-Tributyrin /MT okungu-2.5 kg ngemva kokuyekiswa kwesisu izinsuku ezingu-35 kuthuthukise ukutholakala kwesisindo somzimba ngo-5% kanye nesilinganiso sokuguqulwa kokudla ngamaphuzu amathathu.

I-Tributyrin ingasetshenziswa futhi ebisini njengokufaka esikhundleni sobisi oluphelele futhi iqeda kancane umphumela omubi obangelwa yizinto ezifaka esikhundleni sobisi ekuthuthukisweni kwesisu.