1.Izakhiwo ze-Physicochemical
I-Benzoic acid(benzenecarboxylic acid) iyi-asidi enamakha elula ene-asidi ebuthakathaka (i-dissociation constant 4.20). Incibilika kancane emanzini kodwa incibilika kalula kuzincibilikisi zemvelo njenge-ethanol. Ngenxa ye-lipophilicity yayo eqinile, ingangena kuma-microbial cell membranes futhi ibe nemiphumela elwa namagciwane ngokuvimbela ukumuncwa kwe-amino acid, iphazamise umsebenzi we-enzyme yokuphefumula, nokuvimbela ukusabela kwe-acetyl-CoA condensation.

2.Antimicrobial Spectrum: Isebenza ngokumelene namabhaktheriya, isikhunta, nemvubelo, enemiphumela ethuthukisiwe yokulondoloza kakhulu ezindaweni ezine-asidi (isb, uma iguqulelwa kusawoti we-benzoate).

3.I-Metabolism Nokuphepha

Ezilwaneni, i-benzoic acid igaywa ngokuyinhloko esibindini, futhi ngaphezu kuka-85% ikhishwa emchamweni njenge-hippuric acid, ingashiyi nhlobo insalela futhi ingabangeli ukuphazamiseka ekulinganiseni kwe-acid-base.
Abantu nezingulube bakhombisa izindlela ezifanayo ze-metabolic, cishe nokuphuma okuphelele phakathi kwamahora angama-24, okubonisa ukuphepha okuphezulu.

II. Izicelo Ezicacisiwe Kokuphakelayo

Imithethonqubo kanye Nezilinganiso Zomthamo

EU: Kusukela ngo-2003, i-benzoic acid ivunyelwe njenge-acidifier ekudleni kwezingulube ku-0.5%~1.0%.
China: Kufakwe ohlwini kokubili isilawuli se-pH nesilondolozi ku-Ikhathalogi Yokwengeza Okuphakelayo (2013), ngaphandle kwemikhawulo yedosi ecacile kodwa ireferensi yamazinga okudla angu-0.2~1.0 g/kg.

Imisebenzi kanye Nempumelelo

I-Alternative Antibiotic: Ngemva kokuvinjelwa kwe-EU kwama-antibiotics ngo-2006, i-benzoic acid yaba indawo eyinhloko ngenxa yezindawo zayo zokulwa namagciwane, ikakhulukazi ekuvimbeleni isifo sohudo sangemva kokulunyulwa (i-PWD) kanye nokuthuthukisa ukukhula kwezingulube.
Ukukhula Ukusebenza: Ucwaningo lubonisa ukuthi ukungeza u-0.5% we-benzoic acid kuthuthukisa ukudliwa kanye nokukhula kwesisindo kumazinyane ezingulube alunyuliwe.

Ukuqhathanisa nezinye Izithasiselo

Uma kuqhathaniswa ne-potassium diformate, i-benzoic acid imuncwa ngokushesha kakhulu ngaphambili futhi idinga ubuchwepheshe bokumboza ukuze busebenze ku-hindgut, kanti i-potassium diformate iqondise ngqo i-duodenum, inikeza ukusebenza kahle okuphezulu kwe-antimicrobial.