Igama :γ- i-aminobutyric acid(GABA）

Inombolo ye-CAS: 56-12-2

Omqondofana: 4-Ai-minobutyric acid; I-ammonia butyric acid;I-Pipecolic acid.

1. Umthelela we-GABA ekuphakeleni izilwane udinga ukungaguquguquki ngesikhathi esithile. Ukudla okudliwayo kuhlobene kakhulu nokusebenza kokukhiqizwa kwemfuyo nezinkukhu. Njengomsebenzi wokuziphatha oyinkimbinkimbi, ukudla kulawulwa ikakhulukazi isimiso sezinzwa esiphakathi. Isikhungo sokusutha (i-Ventromedial nucleus ye-hypothalamus) kanye nesikhungo sokuphakela (indawo ye-hypothalamus ehlangothini) zingabalawuli bezilwane.

Isikhungo esiyisisekelo sokudla i-GABA singaheha ukudla kwezilwane ngokuvimbela umsebenzi wesikhungo sokusutha, sithuthukise ikhono lokudla kwezilwane. Ucwaningo oluningi lubonise ukuthi ukujova uhla oluthile lomthamo we-GABA ezindaweni ezihlukene zobuchopho bezilwane kungakhuthaza kakhulu ukuphakelwa kwezilwane futhi kube nomthelela oncike kumthamo. Ukwengeza i-GABA ekudleni okuyisisekelo kwezingulube ezikhuluphalisayo kungakhuphula kakhulu ukudla kwezingulube, kwandise ukukhuluphala, futhi kunganciphisi ukusetshenziswa kwamaprotheni okuphakelayo.

2. Umphumela we-GABA ekugayweni kwamathumbu kanye nohlelo lwe-Endocrine Njenge-neurotransmitter noma i-modulator, i-GABA idlala indima ebanzi ohlelweni lwezinzwa lwe-peripheral Autonomic lwezilwane ezinomgogodla.

3. Umphumela we-GABA ku-motility yamathumbu. I-GABA ikhona kakhulu emgudwini wamathumbu, kanti i-GABA immunoreactive nerve fibers noma amaseli ezinzwa amahle akhona ohlelweni lwezinzwa kanye nolwelwesi lwepheshana lesisu esincelisayo, amaseli e-GABA endocrine nawo asatshalaliswa ku-epithelium ye-Gastric mucosa. I-GABA inomthelela olawulayo kumaseli emisipha abushelelezi emathunjini, amaseli e-endocrine namaseli angewona ama-endocrine. I-Exogenous GABA inomphumela obalulekile wokuvimbela ezingxenyeni zamathumbu ezihlukanisiwe zamagundane, okubonakala ekuphumuleni nasekunciphiseni ukufinyela kwe-amplitude yezingxenye zamathumbu ezihlukanisiwe. Le ndlela yokuvimbela i-GABA kungenzeka ibe ngokuvimbela izinhlelo ze-cholinergic kanye/noma ezingezona ze-cholinergic zamathumbu, Ukusebenza ngaphandle kwesistimu ye-adrenergic; Ingase futhi ibophe ngokuzimela isamukeli se-GABA esihambisanayo kumaseli emisipha abushelelezi wamathumbu.

4. I-GABA ilawula umzimba wezilwane. I-GABA ingaba nemiphumela eminingi ehlukahlukene ohlelweni lwamathumbu njengehomoni yendawo, njengezindlala ezithile namahomoni e-endocrine. Ngaphansi kwezimo ze-in vitro, i-GABA ingashukumisa ukukhiqizwa kwe-hormone yokukhula ngokwenza kusebenze isamukeli se-GABA esiswini. I-hormone yokukhula kwezilwane ingakhuthaza ukuhlanganiswa kwamanye ama-peptide esibindi (njenge-IGF-1), ikhulise izinga lomzimba wamangqamuzana emisipha, ikhulise izinga lokukhula kanye nezinga lokuguqulwa kokudla kwezilwane, Ngesikhathi esifanayo, iphinde yashintsha ukusatshalaliswa kwezakhi zokudla emzimbeni wesilwane; Kungacatshangwa ukuthi umphumela okhuthaza ukukhula we-GABA ungase uhlotshaniswe nokulawulwa kwayo komsebenzi we-hormone yokukhula ngokuthinta umsebenzi wesistimu ye-Endocrine yezinzwa.