Njengomlandeli we-butyric acid,i-tributyl glycerideiyisengezo esihle kakhulu se-butyric acid esinezakhiwo zomzimba nezamakhemikhali ezizinzile, ukuphepha kanye nemiphumela emibi engeyona ubuthi. Ayixazululi nje kuphela inkinga yokuthi i-butyric acid inuka kabi futhi ishintshashintsha kalula, kodwa futhi ixazulula inkinga yokuthi i-butyric acid kunzima ukuyifaka ngqo esiswini nasemathunjini. Inamathuba amaningi okusetshenziswa emkhakheni wokudla kwezilwane. Njengesengezo sokudla,i-tributyl glycerideingasebenza ngqo endleleni yokugaya ukudla yezilwane, inikeze amandla endleleni yamathumbu ezilwane, ithuthukise impilo yamathumbu ezilwane, futhi ilawule ukusebenza kahle kokukhula kwezilwane kanye nesimo sempilo yazo.

1. Thuthukisa ukusebenza kokukhula

Ukwengezwa kwei-tributyl glycerideUkwenyusa ukudla kuye kwasetshenziswa kabanzi ekukhiqizweni kwazo zonke izinhlobo zezilwane. Ukwengeza inani elifanele le-tributyl glyceride ekudleni kungandisa inzuzo yesisindo yansuku zonke yezilwane ezihlolwayo, kunciphise isilinganiso sokudla kwesisindo, futhi kuthuthukise ukusebenza kokukhula kwezilwane. Inani lokwengeza lingu-0.075% ~ 0.250%.

2. Thuthukisa impilo yamathumbu

I-Tributyriningadlala indima ebalulekile empilweni yamathumbu ezilwane ngokuthuthukisa isimo samathumbu kanye nesakhiwo sawo, ilawule ibhalansi yezitshalo zamathumbu, ithuthukise isithiyo samathumbu kanye namandla okulwa ne-antioxidant. Ucwaningo luthole ukuthi ukwengeza i-TB ekudleni kungandisa ukubonakaliswa kweprotheni ye-intestinal tight junction, kukhuthaze ukuthuthukiswa kwe-mucosa yamathumbu, kuthuthukise ukugayeka kwezakhamzimba zokudla, kuthuthukise amandla okulwa ne-antioxidant, kunciphise okuqukethwe kwamagciwane ayingozi endleleni yamathumbu futhi kwandise okuqukethwe kwamagciwane anenzuzo, kukhuthaze ukuthuthukiswa kwamathumbu ezilwane, futhi kuthuthukise impilo yamathumbu ezilwane.

Kunezifundo ezithile ezikhombisile ukuthi ukungezwa kwe-TB ekudleni kungathuthukisa kakhulu ukugayeka okubonakalayo kwamaprotheni angahluziwe, amafutha angahluziwe kanye namandla ezingulube ezisanda kususwa ubisi, futhi ukugayeka kokudla okunempilo kuhlobene kakhulu nempilo yamathumbu ezilwane. Kungabonakala ukuthi i-TB ikhuthaza ukumuncwa nokugaya izakhamzimba emathunjini.

Ukwengezwa kwei-tributyl glyceridekungakhuphula kakhulu ukuphakama kwe-villus kanye nenani le-V/C lomgudu wamathumbu wamachwane ancelisayo, kunciphise okuqukethwe yi-MDA kanye ne-hydrogen peroxide ku-jejunum, kuthuthukise ukusebenza kwe-mitochondrial, kunciphise ukucindezeleka kwe-oxidative kumachwane, futhi kukhuthaze ukukhula kwamathumbu.

Ukwengezwa kwe-tributyl glyceride ene-microcapsulated kungakhuphula kakhulu ukuphakama kwe-villus kwe-duodenum ne-jejunum, kwandise okuqukethwe kwamagciwane e-lactic acid ku-cecum futhi kunciphise okuqukethwe kwe-Escherichia coli, kwenze ngcono isakhiwo sezitshalo zamathumbu ezinkukhu, futhi umphumela we-TB ene-microcapsulated ungcono kunowe-TB ewuketshezi. Ngenxa yendima ekhethekile ye-rumen ezinkukhuni ezincelisayo, kunemibiko embalwa ngemiphumela ye-tributyl glyceride ezinkukhuni ezincelisayo.

Njengezinto zamandla zamathumbu, i-tributyrin ingathuthukisa futhi ilungise ngempumelelo isimo kanye nesakhiwo samathumbu, ithuthukise ukugaya kanye namandla okumunca amathumbu, ikhuthaze ukwanda kwamagciwane azuzisayo emathunjini, ithuthukise isakhiwo sezitshalo zamathumbu, inciphise ukusabela kokucindezeleka kwe-oxidative kwezilwane, ikhuthaze ukukhula kwamathumbu ezilwane, futhi iqinisekise impilo yomzimba.

Ucwaningo luthole ukuthi ukuhlanganiswa kwe-compound kwe-i-tributyrinkanye namafutha e-oregano noma i-methyl salicylate ekudleni kwamachwane aphuciwe kungakhuphula inani le-V/C lamathumbu, kuthuthukise isimo samathumbu samachwane, kwandise kakhulu ubuningi bamaFirmicutes, kunciphise ubuningi be-Proteus, i-Actinobacillus, i-Escherichia coli, njll., kushintshe isakhiwo sezitshalo zamathumbu kanye nama-metabolites, okuzuzisa impilo yamathumbu amachwane aphuciwe, futhi kungathatha indawo yama-antibiotic ekusetshenzisweni kwamachwane aphuciwe.

Ngenjwayelo,i-tributyrininemisebenzi eyahlukahlukene yezinto eziphilayo njengokunikeza amandla emzimbeni, ukugcina ubuqotho bamathumbu, ukulawula isakhiwo sezitshalo zamathumbu, ukubamba iqhaza ekuphenduleni komzimba kanye nokusetshenziswa komzimba, njll. Ingakhuthaza ukuthuthukiswa kwamathumbu ezilwane futhi ithuthukise ukusebenza kokukhula kwezilwane. I-Glyceryl tributylate ingabola yi-pancreatic lipase emathunjini ukuze ikhiqize i-butyric acid kanye ne-glycerol, engasetshenziswa njengomthombo osebenzayo we-butyric acid emathunjini ezilwane. Ayixazululi nje kuphela inkinga yokuthi i-butyric acid kunzima ukuyifaka ekudleni ngenxa yephunga layo kanye nokuguquguquka kwayo, kodwa futhi ixazulula inkinga yokuthi i-butyric acid kunzima ukungena emathunjini ngesisu. Iyisithasiselo se-antibiotic esisebenza kahle kakhulu, esiphephile nesiluhlaza.

Kodwa-ke, ucwaningo lwamanje mayelana nokusetshenziswa kwei-tributyl glycerideekudleni kwezilwane kuncane kakhulu, futhi ucwaningo ngenani, isikhathi, uhlobo kanye nokuhlanganiswa kwe-TB nezinye izakhamzimba alutholakali kahle. Ukuqinisa ukusetshenziswa kwe-tributyl glyceride ekukhiqizweni kwezilwane akugcini nje ngokuhlinzeka ngezindlela ezintsha zokunakekelwa kwempilo yezilwane kanye nokuvimbela izifo, kodwa futhi kungaba nenani elikhulu lokusetshenziswa ekuthuthukisweni kwemithi yokwelapha elwa namagciwane, ngamathuba amaningi okusetshenziswa.