Njengesandulela se-butyric acid,i-tributyl glycerideiyisengezo esihle kakhulu se-butyric acid esinezakhiwo ezinzile zomzimba namakhemikhali, ukuphepha kanye nemiphumela engemihle engenabuthi. Ayixazululi kuphela inkinga ukuthi i-asidi ye-butyric inuka kabi futhi ivuvukala kalula, kodwa futhi ixazulula inkinga yokuthi i-asidi ye-butyric kunzima ukufakwa ngokuqondile esiswini nasemathunjini. Inamathemba okusebenza abanzi emkhakheni wokudla kwezilwane. Njengesengezo sokuphakelayo,i-tributyl glycerideingasebenza ngokuqondile emgudwini wokugaya wezilwane, inikeze amandla endleleni yamathumbu ezilwane, ithuthukise impilo yamathumbu ezilwane, futhi ilawule ukukhula kwezilwane kanye nesimo sempilo.

1. Thuthukisa ukusebenza kokukhula

Ukwengezwa kwei-tributyl glycerideukondla sekusetshenziswe kakhulu ekukhiqizeni zonke izinhlobo zezilwane. Ukwengeza inani elifanele le-tributyl glyceride ekudleni kungakhuphula isilinganiso sesisindo sansuku zonke sezilwane ezihlolwayo, kwehlise isilinganiso sokuphakelayo nesisindo, futhi kuthuthukise ukusebenza kokukhula kwezilwane. Inani elingeziwe ngu-0.075%~0.250%.

2. Thuthukisa impilo yamathumbu

I-Tributyriningadlala indima esebenzayo empilweni yamathumbu esilwane ngokuthuthukisa i-morphology yamathumbu kanye nesakhiwo, ukulawula ibhalansi yezitshalo zamathumbu, ukuthuthukisa umgoqo wamathumbu kanye nomthamo we-antioxidant. Ucwaningo lwathola ukuthi ukwengeza i-TB ekudleni kungakhuphula ukubonakaliswa kwamaprotheni ahlangene emathunjini, kukhuthaze ukuthuthukiswa kwe-mucosa emathunjini, kuthuthukise ukugayeka kokudla okunomsoco, kuthuthukise umthamo we-antioxidant, kunciphise okuqukethwe kwamagciwane ayingozi emgudwini wamathumbu futhi kwandise okuqukethwe kwamagciwane anenzuzo, kukhuthaze ukuthuthukiswa kwamathumbu ezilwane, futhi kuthuthukise impilo yamathumbu ezilwane.

Kukhona ucwaningo oluthile olubonise ukuthi ukungezwa kwe-TB ekudleni kungathuthukisa ngokuphawulekayo ukugayeka kokudla kwamaprotheni, amafutha aluhlaza namandla ezingulube ezilunyuliwe, futhi ukugayeka kokudla okunomsoco kuhlobene eduze nempilo yamathumbu ezilwane. Kuyabonakala ukuthi i-TB ikhuthaza ukumuncwa nokugaya imisoco emathunjini.

Ukwengezwa kwei-tributyl glycerideingakhuphula ngokuphawulekayo ukuphakama kwe-villus kanye nenani le-V/C lepheshana lamathumbu ezingane ezilunyulwayo, inciphise okuqukethwe kwe-MDA ne-hydrogen peroxide ku-jejunum, ithuthukise ukusebenza kwe-mitochondrial, inciphise ukucindezeleka kwe-oxidative kuma-piglets, futhi ikhuthaze ukuthuthukiswa kwamathumbu.

Ukwengezwa kwe-microencapsulated tributyl glyceride kungakhuphula ngokuphawulekayo ukuphakama kwe-villus ye-duodenum ne-jejunum, kwandise okuqukethwe kwamagciwane e-lactic acid ku-cecum futhi kunciphise okuqukethwe kwe-Escherichia coli, kuthuthukise ukwakheka kwezitshalo zamathumbu ezinkukhu zezinkukhu, futhi umphumela we-TB ye-microencapsulated ungcono kune-TB ewuketshezi. Ngenxa yeqhaza elikhethekile le-rumen ezitsheni, kunemibiko embalwa ngemiphumela ye-tributyl glyceride kuma-ruminants.

Njengezinto zamandla zamathumbu, i-tributyrin ingathuthukisa ngempumelelo futhi ilungise i-morphology kanye nesakhiwo samathumbu, ithuthukise ukugayeka kokudla kanye nomthamo wamathumbu, ikhuthaze ukwanda kwamagciwane awusizo emathunjini, ithuthukise ukwakheka kwezitshalo zamathumbu, inciphise ukusabela kokucindezeleka okwenziwe nge-oxidative yezilwane, ikhuthaze impilo yezilwane, iqinisekise ukuthuthukiswa kwamathumbu.

Ucwaningo luthole ukuthi ukungezwa okuhlanganisiwe kwei-tributyrinkanye namafutha e-oregano noma i-methyl salicylate ekudleni kwezingulube ezilunyuliwe kungakhuphula inani le-V / C lamathumbu, kuthuthukise i-morphology yamathumbu ezingulube, kukhulise kakhulu ubuningi be-Firmicutes, kunciphise ukuchichima kwe-Proteus, i-Actinobacillus, i-Escherichia coli, njll. Impilo yamachwane elunyuliwe, futhi angathatha indawo yemithi elwa namagciwane ekufakeni amazinyane alunyuliwe.

Ngenjwayelo,i-tributyrininemisebenzi ehlukahlukene yebhayoloji efana nokunikeza amandla emzimbeni, ukugcina ubuqotho bamathumbu, ukulawula ukwakheka kwezitshalo zamathumbu, ukubamba iqhaza ekuphenduleni kokuzivikela komzimba kanye nokuguquguquka kwe-metabolic, njll. Kungakhuthaza ukuthuthukiswa kwamathumbu ezilwane futhi kuthuthukise ukusebenza kokukhula kwezilwane. I-Glyceryl tributylate ingaboliswa yi-pancreatic lipase emathunjini ukuze ikhiqize i-butyric acid ne-glycerol, engasetshenziswa njengomthombo osebenzayo we-butyric acid emathunjini ezilwane. Ayixazululi kuphela inkinga ukuthi i-butyric acid kunzima ukuyengeza ekudleni ngenxa yephunga layo nokuguquguquka, kodwa futhi ixazulula inkinga yokuthi i-butyric acid kunzima ukungena emathunjini ngokusebenzisa isisu. Kuyinto esebenza kahle kakhulu, ephephile futhi ehlaza esikhundleni sama-antibiotic.

Nokho, ucwaningo lwamanje mayelana nokusetshenziswa kwei-tributyl glycerideekudleni kwezilwane kumbalwa uma kuqhathaniswa, kanti ucwaningo lwenani, isikhathi, uhlobo kanye nenhlanganisela ye-TB nezinye izakhi alukho. Ukuqinisa ukusetshenziswa kwe-tributyl glyceride ekukhiqizeni izilwane akukwazi nje ukunikeza izindlela ezintsha zokunakekelwa kwempilo yezilwane kanye nokuvimbela izifo, kodwa futhi kube nenani elikhulu lesicelo ekuthuthukisweni kwama-antibiotic esikhundleni, namathemba okufaka isicelo.